Elaeagnus conferta Roxb. and chemotherapeutic agents-based anticancer therapy: Harnessing the dual approach

被引：1

作者：

Gupta, Mukta ^{[1
]}

Gulati, Monica ^{[1
,2
]}

Kapoor, Bhupinder ^{[1
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[2] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW 2007, Australia

来源：

MEDICAL HYPOTHESES | 2023年 / 175卷

关键词：

Cancer; Elaeagnus conferta Roxb; Anti; -oxidant; Ascorbic acid; Chemotherapy; Quercetin; VITAMIN-C; CANCER STATISTICS; SUPPLEMENT USE; WESTERN-GHATS; QUERCETIN; ACID;

D O I：

10.1016/j.mehy.2023.111075

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer is the second leading cause of mortality globally and epidemiological evidences indicate that anti-oxidant rich diet reduces the risk of cancer. Recently, the alarming escalations of cancer further warrants better understanding of optimum therapeutic treatment strategies for cancer. Although number of conventional approaches such as chemotherapy, radiotherapy and surgical interventions are available for treating malignant tumors as well as localized lesions, they are associated with many adverse effects. Therefore, combating oxidative stress along with reducing adverse effects of chemotherapy could be the choice of treatment regimen for cancer. Elaeagnus conferta Roxb. is well reported for its ethnic use as anticancer and anti-oxidant. The phytochemical screening of E. conferta Roxb. seeds indicates the presence of bioactive constituents including quercetin, ascorbic acid, oleic acid and stearic acid, with immense anti-oxidant potential. Therefore, it is proposed that a combination of extract of E. conferta Roxb. with chemotherapeutic drugs (cisplatin, doxorubicin and paclitaxel) could be an effective multi-target approach for combating cancer while curbing adverse effects of chemotherapy.

引用

页数：5