In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022

被引：17

作者：

Codda, Giulia ^{[1
]}

Willison, Edward ^{[2
]}

Magnasco, Laura ^{[3
]}

Morici, Paola ^{[2
]}

Giacobbe, Daniele Roberto ^{[3
,4
]}

Mencacci, Antonella ^{[5
,6
]}

Marini, Daniele ^{[5
,6
]}

Mikulska, Malgorzata ^{[3
,4
]}

Bassetti, Matteo ^{[3
,4
]}

Marchese, Anna ^{[1
,2
]}

Di Pilato, Vincenzo ^{[1
]}

机构：

[1] Univ Genoa, Dept Surg Sci & Integrated Diagnost DISC, Genoa, Italy

[2] IRCCS Osped Policlin San Martino, Microbiol Unit, Genoa, Italy

[3] IRCCS Osped Policlin San Martino, Infect Dis Unit, Genoa, Italy

[4] Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy

[5] Univ Perugia, Dept Med, Med Microbiol, Perugia, Italy

[6] Santa Maria Misericordia Hosp, Microbiol, Perugia, Italy

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 14期

关键词：

D O I：

10.2807/1560-7917.ES.2023.28.14.2300161

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1S639F and FKS1F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.

引用

页数：7