Copper-Catalyzed (3+2) Annulation of 5-Ethynyloxazolidine-2,4-diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

被引：0

作者：

Du, Juan ^{[1
,2
]}

Qu, Siting ^{[1
,2
]}

Yu, Zhiyuan ^{[1
,2
]}

Duan, Zeqing ^{[1
,2
]}

Yu, Songcheng ^{[3
]}

Wu, Yongjun ^{[3
]}

Zheng, Bing ^{[1
,2
]}

Guo, Hongchao ^{[1
,2
]}

机构：

[1] China Agr Univ, Dept Chem, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China

[2] China Agr Univ, Innovat Ctr Pesticide Res, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China

[3] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 39期

关键词：

Copper; annulation; decarboxylation; dihydrofuran; BAYLIS-HILLMAN CARBONATES; ASYMMETRIC PROPARGYLIC DEAROMATIZATION; ENANTIOSELECTIVE SYNTHESIS; BETA-KETOESTERS; CYCLIZATION REACTIONS; ALLENYLIDENE LIGAND; SUBSTITUTED FURANS; 4+2 CYCLOADDITION; ESTERS; AMINATION;

D O I：

10.1002/slct.202303126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper-catalyzed (3+2) annulation of 5-ethynyloxazolidine-2,4-diones with acylacetonitriles worked well under mild reaction conditions to afford biologically important 2,3-dihydrofuran derivatives having an amide moiety in moderate to high yields. A wide scope of easily accessible 5-ethynyloxazolidine-2,4-diones and acylacetonitriles were tolerated. The successful scale-up reaction demonstrated that the reaction is a useful method for the synthesis of 2,3-dihydrofuran derivatives.

引用

页数：6

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