Hepatic inactivation of the epigenetic regulators Suv420h1-h2 mitigates NAFLD development and progression in mice

被引：0
|
作者：
Pagani, Alessia [1 ]
Furiosi, Valeria [1 ]
Pettinato, Mariateresa [1 ]
Volpe, Letizia Bavuso [1 ]
Altamura, Sandro [2 ,3 ]
Nai, Antonella [1 ,4 ]
Gabellini, Davide [5 ]
Pedrotti, Simona [5 ]
Silvestri, Laura [1 ,4 ]
机构：
[1] IRCCS Osped San Raffaele, Regulat Iron Metab Unit, Div Genet & Cell Biol, Milan, Italy
[2] Heidelberg Univ, Heidelberg, Germany
[3] Dept Pediat Hematol Oncol & Immunol, Mol Med Partnership Unit MMPU, Heidelberg, Germany
[4] Univ Vita Salute San Raffaele, Milan, Italy
[5] IRCCS Osped San Raffaele, Div Genet & Cell Biol, Gene Express & Muscular Distrophy Unit, Milan, Italy
来源：
JOURNAL OF HEPATOLOGY | 2023年 / 78卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
WED-423
引用
收藏
页码：S749 / S750
页数：2
相关论文
共 49 条
  • [1] Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2
    Wu, Hong
    Siarheyeva, Alena
    Zeng, Hong
    Lam, Robert
    Dong, Aiping
    Wu, Xian-Hui
    Li, Yanjun
    Schapira, Matthieu
    Vedadi, Masoud
    Min, Jinrong
    FEBS LETTERS, 2013, 587 (23): : 3859 - 3868
  • [2] A novel role for the epigenetic regulator SUV420H1 in MASLD and its complications
    Pagani, Alessia
    Volpe, Letizia Bavuso
    Pettinato, Mariateresa
    Malvestiti, Francesco
    Furiosi, Valeria
    Carleo, Rossana
    Nai, Antonella
    Valenti, Luca
    Silvestri, Laura
    JOURNAL OF HEPATOLOGY, 2024, 80 : S571 - S571
  • [3] SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer
    Viotti, Manuel
    Wilson, Catherine
    McCleland, Mark
    Koeppen, Hartmut
    Haley, Benjamin
    Jhunjhunwala, Suchit
    Klijn, Christiaan
    Modrusan, Zora
    Arnott, David
    Classon, Marie
    Stephan, Jean-Philippe
    Mellman, Ira
    JOURNAL OF CELL BIOLOGY, 2018, 217 (02): : 763 - 777
  • [4] Comparative Analyses of SUV420H1 Isoforms and SUV420H2 Reveal Differences in Their Cellular Localization and Effects on Myogenic Differentiation
    Tsang, Leanna W. K.
    Hu, Ninghe
    Underhill, D. Alan
    PLOS ONE, 2010, 5 (12):
  • [5] Molecular analysis of histone methyltransferases SUV420H1 and SUV420H2 and their potential as prognostic markers in head and neck cancer
    Ramos, Doralina do Amaral Rabello
    Ribeiro, Beatriz Itai Haupt
    de Castro, Tercia Maria Mendes Lousa
    Ferreira, Vivian D'Afonseca da Silva
    Takano, Gustavo Henrique Soares
    Duarte, Eliza Carla Barroso
    Carneiro, Fabiana Pirani
    Silva, Fabio Pittella
    CANCER RESEARCH, 2017, 77
  • [6] Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma
    Ryu, Tae Young
    Lee, Jinkwon
    Kang, Yunsang
    Son, Mi-Young
    Kim, Dae-Soo
    Lee, Youn su
    Kim, Mi-Young
    Cho, Hyun-Soo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 663 : 41 - 46
  • [7] Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    Marta García-Cao
    Roderick O'Sullivan
    Antoine H F M Peters
    Thomas Jenuwein
    María A Blasco
    Nature Genetics, 2004, 36 : 94 - 99
  • [8] Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1
    Huang, Li
    Wang, Youwang
    Long, Haizhen
    Zhu, Haoqiang
    Wen, Zengqi
    Zhang, Liwei
    Zhang, Wenhao
    Guo, Zhenqian
    Wang, Longge
    Tang, Fangyi
    Hu, Jie
    Bao, Keyan
    Zhu, Ping
    Li, Guohong
    Zhou, Zheng
    MOLECULAR CELL, 2023, 83 (16) : 2884 - +
  • [9] Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    García-Cao, M
    O'Sullivan, R
    Peters, AHFM
    Jenuwein, T
    Blasco, MA
    NATURE GENETICS, 2004, 36 (01) : 94 - 99
  • [10] Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression
    Boonsanay, Boonsanay
    Mosa, Mohammed H.
    Looso, Mario
    Weichenhan, Dieter
    Ceteci, Fatih
    Pudelko, Lorenz
    Lechel, Andre
    Michel, Christian S.
    Kuenne, Carsten
    Farin, Henner F.
    Plass, Christoph
    Greten, Florian R.
    GASTROENTEROLOGY, 2023, 164 (02) : 214 - 227
12345