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The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren's syndrome, cancers, and cancer metabolism

被引：4
|
作者：
Hsu, Chueh-Hsuan [1 ]
Yu, Yung-Luen [1 ,2 ,3 ,4 ]
机构：
[1] China Med Univ, Grad Inst Biomed Sci, Coll Med, Taichung 40402, Taiwan
[2] Inst Translat Med & New Drug Dev, Taichung 40402, Taiwan
[3] China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan
[4] Asia Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan
来源：
CANCER CELL INTERNATIONAL | 2023年 / 23卷 / 01期
关键词：
TRIM21/Ro52; Anti-Ro52; antibody; Systemic lupus erythematosus; Primary Sjogren's syndrome; Cancer immunology; Cancer metabolism; PRIMARY SJOGRENS-SYNDROME; CYTOSOLIC FC-RECEPTOR; B-CELL LYMPHOMA; ANTI-RO52; ANTIBODY; SALIVARY-GLANDS; POOR-PROGNOSIS; E3; LIGASE; EXPRESSION; RISK; OVARIAN;
D O I：
10.1186/s12935-023-03143-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Protein tripartite motif-containing 21 (TRIM21/Ro52), an E3 ubiquitin ligase, is an essential regulator of innate immunity, and its dysregulation is closely associated with the development of autoimmune diseases, predominantly systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). TRIM21 /Ro52 also features anti-cancer and carcinogenic functions according to different malignancies. The interconnected role of TRIM21/Ro52 in regulating autoimmunity and cell metabolism in autoimmune diseases and malignancies is implicated. In this review, we summarize current findings on how TRIM21/Ro52 affects inflammation and tumorigenesis, and investigate the relationship between TRIM21/Ro52 expression and the formation of lymphoma and breast cancer in SLE and pSS populations.
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页数：12
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