Boosting Luminescence Efficiency of Near-Infrared-II Aggregation-Induced Emission Luminogens via a Mash-Up Strategy of π-Extension and Deuteration for Dual-Model Image-Guided Surgery

被引：14

作者：

Ma, Fulong ^{[1
]}

Jia, Qian ^{[1
,2
]}

Deng, Ziwei ^{[1
]}

Wang, Bingzhe ^{[3
]}

Zhang, Siwei ^{[4
]}

Jiang, Jinhui ^{[1
]}

Xing, Guichuan ^{[3
]}

Wang, Zhongliang ^{[2
]}

Qiu, Zijie ^{[1
]}

Zhao, Zheng ^{[1
,5
]}

Tang, Ben Zhong ^{[1
,4
]}

机构：

[1] Chinese Univ Hong Kong Shenzhen CUHK Shenzhen, Affiliated Hosp 2, Clin Translat Res Ctr Aggregat Induced Emiss, Sch Med,Sch Sci & Engn,Shenzhen Inst Aggregate Sci, Shenzhen 518172, Guangdong, Peoples R China

[2] Xidian Univ, Engn Res Ctr Mol & Neuroimaging, Sch Life Sci & Technol, Lab Mol Imaging & Translat Med MITM,Minist Educ, Xian 710126, Peoples R China

[3] Univ Macau, Inst Appl Phys & Mat Engn, Taipa 999078, Macao, Peoples R China

[4] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong Branch, Hong Kong Branch,Kowloon, Hong Kong 999077, Peoples R China

[5] HKUST Shenzhen Res Inst, South Area Hitech Pk, Shenzhen 518057, Guangdong, Peoples R China

来源：

ACS NANO | 2024年 / 18卷 / 13期

基金：

中国国家自然科学基金;

关键词：

NIR-II fluorescence; aggregation-induced emission; intramolecular motion; radiative and nonradiative decay; image-guided surgery; FLUORESCENT-PROBES; ORGANELLES;

D O I：

10.1021/acsnano.3c11078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The simultaneous pursuit of accelerative radiative and restricted nonradiative decay is of tremendous significance to construct high-luminescence-efficiency fluorophores in the second near-infrared wavelength window (NIR-II), which is seriously hindered by the energy gap laws. Herein, a mash-up strategy of pi-extension and deuteration is proposed to efficaciously ameliorate the knotty problem. By extending the pi-conjugation of the aromatic fragment and introducing an isotope effect to the aggregation-induced emission luminogen (AIEgen), an improved oscillator strength (f), coupled with suppressed deformation and high-frequency oscillation in the excited state, are successively implemented. In this case, a faster rate of radiative decay (k(r)) and restricted nonradiative decay (k(nr)) are simultaneously achieved. Moreover, the preeminent emissive property of AIEgen in the molecular state could be commendably inherited by the aggregates. The corresponding NIR-II emissive AIEgen-based nanoparticles display high brightness, large Stokes shift, and superior photostability simultaneously, which can be applied for image-guided cancer and sentinel lymph node (SLN) surgery. This work thus provides a rational roadmap to improve the luminescence efficiency of NIR-II fluorophores for biomedical applications.

引用

页码：9431 / 9442

页数：12