Glioma-associated mesenchymal stem cells

被引：7
|
作者：
Kang, Qing-Mei [1 ,2 ,3 ,4 ,5 ,6 ]
Wang, Jun [1 ,2 ,4 ,5 ,6 ]
Chen, Shi-Man [1 ,2 ,4 ,5 ,6 ]
Song, Si-Rong [1 ,2 ,4 ,5 ,6 ]
Yu, Shi-Cang [1 ,2 ,4 ,5 ,6 ,7 ]
机构：
[1] Southwest Hosp, Inst Pathol, Dept Stem Cell & Regenerat Med, Chongqing 400038, Peoples R China
[2] Southwest Hosp, Southwest Canc Ctr, Chongqing 400038, Peoples R China
[3] Southwest Med Univ, Dept Pathol, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China
[4] Minist Sci & Technol, Int Joint Res Ctr Precis Biotherapy, Chongqing 400038, Peoples R China
[5] Minist Educ, Key Lab Canc Immunopathol, Chongqing 400038, Peoples R China
[6] Jin Feng Lab, Chongqing 401329, Peoples R China
[7] 30 Gaotanyan St, Chongqing, Peoples R China
来源：
BRAIN | 2024年 / 147卷 / 03期
基金：
中国国家自然科学基金;
关键词：
glioma; mesenchymal stem cells; microenvironment; central nervous system; BONE-MARROW; STROMAL CELLS; CORD BLOOD; ADIPOSE-TISSUE; INDUCED MIGRATION; HIGH-GRADE; GROWTH; DIFFERENTIATION; PROLIFERATION; EXPRESSION;
D O I：
10.1093/brain/awad360
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent studies have revealed that glioma-associated mesenchymal stem cells play instrumental roles in tumorigenesis and tumour progression and cannot be ignored as a cellular component of the glioma microenvironment. Nevertheless, the origin of these cells and their roles are poorly understood. The only relevant studies have shown that glioma-associated mesenchymal stem cells play a large role in promoting tumour proliferation, invasion and angiogenesis.This review provides a comprehensive summary of their discovery and definition, origin, differences from other tissue-derived mesenchymal stem cells, spatial distribution, functions and prognostic and therapeutic opportunities to deepen the understanding of these cells and provide new insight into the treatment of glioma. Glioma-associated mesenchymal stem cells play instrumental roles in tumorigenesis and tumour progression. Kang et al. review the origins, spatial distribution and functions of these cells, and consider how targeting them could improve the treatment of glioma.
引用
收藏
页码：755 / 765
页数：11
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