Macrophage-Biomimetic Nanoplatform-Based Therapy for Inflammation-Associated Diseases

被引:12
|
作者
Qu, Ying [1 ,2 ,3 ]
Chu, Bingyang [1 ,2 ,3 ]
Li, Jianan [1 ,2 ,3 ]
Deng, Hanzhi [1 ,2 ,3 ]
Niu, Ting [1 ,2 ,3 ]
Qian, Zhiyong [1 ,2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
inflammation-associated diseases; macrophage-biomimetic nanoplatforms; macrophage membrane-coated nanoparticles; macrophage-derived vesicles; macrophage-based delivery platform; EXTRACELLULAR VESICLES EXOSOMES; MEMBRANE-COATED NANOPARTICLES; TARGETED DRUG-DELIVERY; BLOOD-BRAIN-BARRIER; RHEUMATOID-ARTHRITIS; ANTIRETROVIRAL DRUG; ACUTE-PANCREATITIS; ANTI-INFLAMMATION; MURINE MODEL; PATHOGENESIS;
D O I
10.1002/smtd.202301178
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Inflammation-associated diseases are very common clinically with a high incidence; however, there is still a lack of effective treatments. Cell-biomimetic nanoplatforms have led to many breakthroughs in the field of biomedicine, significantly improving the efficiency of drug delivery and its therapeutic implications especially for inflammation-associated diseases. Macrophages are an important component of immune cells and play a critical role in the occurrence and progression of inflammation-associated diseases while simultaneously maintaining homeostasis and modulating immune responses. Therefore, macrophage-biomimetic nanoplatforms not only inherit the functions of macrophages including the inflammation tropism effect for targeted delivery of drugs and the neutralization effect of pro-inflammatory cytokines and toxins via membrane surface receptors or proteins, but also maintain the functions of the inner nanoparticles. Macrophage-biomimetic nanoplatforms are shown to have remarkable therapeutic efficacy and excellent application potential in inflammation-associated diseases. In this review, inflammation-associated diseases, the physiological functions of macrophages, and the classification and construction of macrophage-biomimetic nanoplatforms are first introduced. Next, the latest applications of different macrophage-biomimetic nanoplatforms for the treatment of inflammation-associated diseases are summarized. Finally, challenges and opportunities for future biomedical applications are discussed. It is hoped that the review will provide new ideas for the further development of macrophage-biomimetic nanoplatforms. This review provides a detail overview of macrophage-biomimetic nanoplatforms and their application in inflammation-associated diseases. First, inflammation-associated diseases, the physiological functions of macrophages, and the classification and construction of macrophage-biomimetic nanoplatforms are introduced. Next, the latest applications of different macrophage-biomimetic nanoplatforms for the treatment of inflammation-associated diseases are summarized. Finally, challenges and opportunities for future biomedical applications are discussed.image
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页数:29
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