Two new antimicrobial monoterpenoid indole alkaloids from the roots of Rauvolfia yunnanensis

被引：2

作者：

Wu Hao ^{[1
,2
]}

Qin Ma-Long ^{[1
,2
]}

Fan Kun ^{[1
,2
]}

Gao Wen ^{[1
,2
]}

Guo Rui-Rong ^{[1
,2
]}

Yin Shan-Ze ^{[1
,2
]}

Hu Wei-Yan ^{[1
,2
]}

Zhang Lan-Chun ^{[1
,2
]}

Zhang Rong-Ping ^{[3
]}

Yu Hao-Fei ^{[1
,2
]}

Li Yu-Peng ^{[1
,2
]}

Ding Cai-Feng ^{[1
,2
]}

机构：

[1] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650031, Yunnan, Peoples R China

[2] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650031, Yunnan, Peoples R China

[3] Yunnan Univ Tradit Chinese Med, Yunnan Key Lab Southern Med Resources, Kunming 650500, Yunnan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Apocynaceae; Rauvolfia yunnanensis; monoterpenoid indole alkaloids; antimicrobial activity; LEAVES;

D O I：

10.1080/10286020.2022.2104258

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new monoterpenoid indole alkaloids 3-hydroxylochnerine (1) and 10-hydroxyvinorine (2) were isolated from the roots of Rauvolfia yunnanensis. Their structures were elucidated based on the analysis of spectroscopic data and ECD calculation. Both compounds exhibited potent antimicrobial activity against Bacillus subtilis and Escherichia coli, and their activities were comparable to the well-known antibacterial drug berberine.

引用

页码：429 / 437

页数：9

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