mRNA vaccine in cancer therapy: Current advance and future outlook

被引：15

作者：

Li, Youhuai ^{[1
]}

Wang, Mina ^{[2
,3
]}

Peng, Xueqiang ^{[4
]}

Yang, Yingying ^{[5
]}

Chen, Qishuang ^{[2
]}

Liu, Jiaxing ^{[4
]}

She, Qing ^{[1
]}

Tan, Jichao ^{[1
]}

Lou, Chuyuan ^{[6
]}

Liao, Zehuan ^{[7
,8
]}

Li, Xuexin ^{[9
]}

机构：

[1] Baoji Municipal Cent Hosp, Dept Breast Surg, Baoji, Shaanxi, Peoples R China

[2] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Acupuncture & Moxibust, Beijing Key Lab Acupuncture Neuromodulat, Beijing, Peoples R China

[4] China Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shenyang, Peoples R China

[5] Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Inst Maternal Fetal Med & Gynecol Oncol, Clin Res Ctr,Shanghai Key Lab Maternal Fetal Med,S, Shanghai, Peoples R China

[6] Xian Peoples Hosp, Xian Hosp 4, Dept Ophthalmol, Xian, Shaanxi, Peoples R China

[7] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore

[8] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Solna, Sweden

[9] Karolinska Inst, Dept Med Biochem & Biophys MBB, Biomed, Stockholm, Sweden

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2023年 / 13卷 / 08期

基金：

中国博士后科学基金;

关键词：

cancer; cancer vaccine; immunology; immunotherapy; mRNA vaccine; DENDRITIC CELLS; IN-VITRO; TRANSFECTION EFFICIENCY; COVID-19; VACCINES; IMMUNE-RESPONSE; GENE-EXPRESSION; DNA-SEQUENCES; CAP-ANALOGS; DELIVERY; NANOPARTICLES;

D O I：

10.1002/ctm2.1384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low side effects and lower cost of acquisition. In this review, we elaborated on the development of cancer vaccines and mRNA cancer vaccines, as well as the potential biological mechanisms of mRNA cancer vaccines and the latest progress in various tumour treatments, and discussed the challenges and future directions for the field.

引用

页数：28

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