Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries

被引：1

作者：

Stepanova, Olga Vladislavovna ^{[1
,2
,6
]}

Fursa, Grigorii Andreevich ^{[1
]}

Andretsova, Svetlana Sergeevna ^{[1
,3
]}

Shishkina, Valentina Sergeevna ^{[1
]}

Voronova, Anastasia Denisovna ^{[1
]}

Chadin, Andrey Viktorovich ^{[1
]}

Karsuntseva, Ekaterina Konstantinovna ^{[1
]}

Reshetov, Igor Vladimirovich ^{[4
]}

Chekhonin, Vladimir Pavlovich ^{[1
,5
]}

机构：

[1] VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Dept Basic & Appl Neurobiol, Moscow 119034, Russia

[2] Natl Med Res Ctr Cardiol, Dept Neurohumoral & Immunol Res, Moscow 121552, Russia

[3] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119991, Russia

[4] IM Sechenov First Moscow State Med Univ, Dept Plast Surg, Moscow 119435, Russia

[5] NI Pirogov Russian Natl Res Med Univ, Dept Med Nanobiotechnol, Moscow 117997, Russia

[6] VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Dept Basic & Appl Neurobiol, 23 Kropotkinsky Lane, Moscow 119034, Russia

来源：

WORLD JOURNAL OF CLINICAL CASES | 2023年 / 11卷 / 02期

关键词：

Olfactory mucosa cells; Neurotrophic factors; Cell therapy; Injury of spinal cord; Three-dimensional bioprinting; Four-dimensional bioprinting; MESENCHYMAL STEM-CELLS; NERVE GROWTH-FACTOR; ENSHEATHING CELLS; NEUROTROPHIC FACTOR; AXONAL REGENERATION; FUNCTIONAL RECOVERY; RUBROSPINAL NEURONS; FACTOR PROMOTES; GENE DELIVERY; SCHWANN-CELLS;

D O I：

10.12998/wjcc.v11.i2.322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The review focuses on the most important areas of cell therapy for spinal cord injuries. Olfactory mucosa cells are promising for transplantation. Obtaining these cells is safe for patients. The use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord injuries. These cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord injuries. In addition, it is possible to increase the content of neurotrophic factors, at the site of injury, exogenously by the direct injection of neurotrophic factors or their delivery using gene therapy. The advantages of olfactory mucosa cells, in combination with neurotrophic factors, open up wide possibilities for their application in three-dimensional and four-dimensional bioprinting technology treating spinal cord injuries.

引用

页码：322 / 331

页数：10

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Svetlana Sergeevna Andretsova
Valentina Sergeevna Shishkina
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