Triethylammonium 2-(3-Hydroxy-2-oxoindolin-3-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-olate

被引：1
|
作者：
Ryzhkova, Yuliya E. E. [1 ]
Ryzhkov, Fedor V. V. [1 ]
Elinson, Michail N. N. [1 ]
机构：
[1] Russian Acad Sci, N D Zelinsky Inst Organ Chem, 47 Leninsky Prospekt, Moscow 119991, Russia
来源：
MOLBANK | 2023年 / 2023卷 / 01期
关键词：
dimedone; isatin; triethylamine; ammonium salt; ion pair; CYCLIC 1,3-DIKETONES; ALDOL REACTION; SCAFFOLD; ISATIN; INHIBITORS; ACID;
D O I：
10.3390/M1589
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In recent years, the application of privileged structures has become a powerful approach in the discovery of new biologically active molecules. Ion pairing is a strategy used to enhance the permeation of ionized topical drugs. A convenient and efficient method for the synthesis of triethylammonium 2-(3-hydroxy-2-oxoindolin-3-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-olate has been developed. The presented protocol includes an aldol reaction and the formation of an ammonium salt. Triethylamine is both a reactant and a catalyst in the process. The structure of the synthesized title compound has been established by H-1, C-13-NMR and IR spectroscopy, mass spectrometry, and elemental analysis.
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页数：7
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