Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars

被引：1
|
作者：
Deepanjali, Megarasu [1 ]
Prasad, Tangutur Srinivasa [1 ]
Manodh, Pedamally [1 ]
机构：
[1] Meenakshi Ammal Dent Coll & Hosp, Chennai, Tamil Nadu, India
来源：
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG | 2023年 / 27卷 / 03期
关键词：
Simvastatin; Bone morphogenetic protein; Gelatin sponge;
D O I：
10.1007/s10006-022-01081-y
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Purpose The aim of this study was to assess the efficacy of simvastatin in bone regeneration in extraction sockets of mandibular third molars using cone beam computed tomography (CBCT) at 6th post-operative month. Methods This is a prospective randomized split-mouth study involving 15 patients who underwent surgical extraction of bilaterally impacted mandibular third molars with similar morphology on the same day. The efficacy of drug was analyzed by implanting 10 mg of simvastatin into the socket (study site) and observations were made over 6 months to compare the healing with the control site. Results The study results demonstrated a statistically significant difference in bone regeneration: mean gray value of 429.133 in study site compared with mean gray value of 310.153 in the control site. Conclusion These values demonstrate significant change in bone regeneration in simvastatin site as compared to that of control site.
引用
收藏
页码：427 / 432
页数：6
相关论文
共 50 条
  • [1] Efficacy of simvastatin in bone regeneration after surgical removal of mandibular third molars
    Megarasu Deepanjali
    Tangutur Srinivasa Prasad
    Pedamally Manodh
    [J]. Oral and Maxillofacial Surgery, 2023, 27 : 427 - 432
  • [2] Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study
    Chauhan A.S.
    Maria A.
    Managutti A.
    [J]. Journal of Maxillofacial and Oral Surgery, 2015, 14 (3) : 578 - 585
  • [3] Efficacy of Simvastatin and Gel foam Combination Local Application on Bone Density, after Surgical Removal of Mandibular Third Molars
    Mahdi, Hayder Salih
    Al-Adili, Sahar Sh
    [J]. JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE, 2021, 9 (07): : 11 - 16
  • [4] Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars
    Kaur P.
    Maria A.
    [J]. Journal of Maxillofacial and Oral Surgery, 2013, 12 (1) : 51 - 59
  • [5] Efficacy of platelet rich plasma in bone regeneration after surgical removal of impacted bilateral mandibular third molars: pilot study
    Gawande P.D.
    Halli R.
    [J]. Journal of Maxillofacial and Oral Surgery, 2009, 8 (4) : 301 - 307
  • [6] Efficacy of preemptive lornoxicam on postoperative analgesia after surgical removal of mandibular third molars
    Zor, Zeynep Fatma
    Isik, Berrin
    Cetiner, Sedat
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2014, 117 (01): : 27 - 31
  • [7] Evaluation of the Efficacy of Simvastatin in Bone Regeneration after Surgical Removal of Bilaterally Impacted Third Molars-A Split-Mouth Randomized Clinical Trial
    Degala, Saikrishna
    Bathija, Nikita A.
    [J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2018, 76 (09) : 1847 - 1858
  • [8] Inability to work after surgical removal of mandibular third molars
    Berge, TI
    [J]. ACTA ODONTOLOGICA SCANDINAVICA, 1997, 55 (01) : 64 - 69
  • [9] The surgical removal of mandibular third molars: A study in decision making
    Bataineh, AB
    Albashaireh, ZS
    Hazza'a, AM
    [J]. QUINTESSENCE INTERNATIONAL, 2002, 33 (08): : 613 - 617
  • [10] Primary and Secondary Closure of the Surgical Wound After Removal of Impacted Mandibular Third Molars
    Khande K.
    Saluja H.
    Mahindra U.
    [J]. Journal of Maxillofacial and Oral Surgery, 2011, 10 (2) : 112 - 117
12345