Hypoxia Sensing and Responses in Parkinson's Disease

被引：1

作者：

Burtscher, Johannes ^{[1
]}

Duderstadt, Yves ^{[2
,3
,4
]}

Gatterer, Hannes ^{[5
]}

Burtscher, Martin ^{[6
]}

Vozdek, Roman ^{[7
]}

Millet, Gregoire P. ^{[1
]}

Hicks, Andrew A. ^{[7
]}

Ehrenreich, Hannelore ^{[8
,9
]}

Kopp, Martin ^{[6
]}

机构：

[1] Univ Lausanne, Inst Sport Sci, CH-1015 Lausanne, Switzerland

[2] Univ Hosp Magdeburg, Div Cardiol & Angiol, D-39120 Magdeburg, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Res Grp Neuroprotect, D-39120 Magdeburg, Germany

[4] Otto Von Guericke Univ, Dept Sports Sci, D-39120 Magdeburg, Germany

[5] Eurac Res, Inst Mt Emergency Med, I-39100 Bolzano, Italy

[6] Univ Innsbruck, Dept Sport Sci, A-6020 Innsbruck, Austria

[7] Eurac Res, Inst Biomed, Via Alessandro Volta 21, I-39100 Bolzano, Italy

[8] Max Planck Inst Multidisciplinary Sci, Clin Neurosci, D-37075 Gottingen, Germany

[9] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Expt Med, D-68159 Mannheim, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 03期

关键词：

Parkinson's disease; neurodegeneration; hypoxia; mitochondria; synuclein; respiratory diseases; INTERMITTENT HYPOXIA; NEUROTROPHIC FACTOR; TYROSINE-HYDROXYLASE; DOPAMINE; ASSOCIATION; ACTIVATION; BDNF; VULNERABILITY; DYSFUNCTION; PLASTICITY;

D O I：

10.3390/ijms25031759

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential.

引用

页数：13

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