Need for enrichment of lutetium isotope and design of a laser based separator module

被引：3
|
作者：
Majumder, A. [1 ]
Pulhani, A. K. [1 ]
Ghosh, A. [1 ,2 ]
Singh, P. [2 ]
Maiti, N. [1 ,2 ]
机构：
[1] Bhabha Atom Res Ctr, Laser & Plasma Technol Div, Mumbai 400085, India
[2] Homi Bhabha Natl Inst, Mumbai 400085, India
来源：
APPLIED RADIATION AND ISOTOPES | 2023年 / 202卷
关键词：
Lutetium-therapy; Radioisotopes; Neutron-activation; Specific activity; Enrichment; AVLIS; Uranium; Tunable-laser; Atomic-beam; Ion extraction; Photoplasma; COPPER-VAPOR-LASER; RECEPTOR RADIONUCLIDE THERAPY; DIRECT NEUTRON-ACTIVATION; HIGH-REPETITION-RATE; SELECTIVE PHOTOIONIZATION; NO-CARRIER; HIGH-POWER; HYPERFINE-STRUCTURE; RESEARCH REACTOR; ION EXTRACTION;
D O I：
10.1016/j.apradiso.2023.111038
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Lutetium-177 radio-pharmaceutical has become an important theranostic candidate in cancer treatment. Its availability from bench-to-bed requires strategic implementation of isotope-enrichment, neutron-irradiation and radio-chemical techniques. In this paper, the need for enrichment of lutetium-176 is emphasized by estimating specific activity of lutetium-177 as a function of enrichment percentage for typical neutron flux available at Dhruva reactor, India. A novel Atomic Vapour Laser Isotope Separation (AVLIS) module for lutetium-176 enrichment is designed to meet the above requirement. The paper documents its characteristics and production estimates. The design is carried out after critical assessment and evaluation of available AVLISinfrastructure in the country. Outline of lutetium-177 enrichment, capable of producing non-carrier-added lutetium is also provided. This work concludes that India has taken a step forward towards self-reliance (Atmanirbhar Bharat) in securing the supply chain of lutetium-177.
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页数：18
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