Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride

被引：2
|
作者：
Dangre, Pankaj [1 ,2 ]
Sonawane, Kajal [2 ]
Moravkar, Kailas [2 ]
Pethe, Anil [1 ]
Chalikwar, Shailesh [2 ]
Borse, Vivek [3 ]
机构：
[1] DMIHER DU, Datta Meghe Coll Pharm, Dept Pharmaceut, Wardha, India
[2] RC Patel Inst Pharmaceut Educ & Res, Dept Ind Pharm & Pharmaceut Qual Assurance, Shirpur, India
[3] Natl Inst Pharmaceut Educ & Res, Dept Med Devices, NanoBioSens Lab, Hyderabad, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 13期
关键词：
Layer-by-layer; buspirone HCl; hybrid nanoparticles; polyelectrolytes multilayer; high-pressure homogenization; STATISTICAL OPTIMIZATION; CONTROLLED DELIVERY; FORMULATION; EFFICACY;
D O I：
10.1080/00914037.2023.2255720
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 +/- 4.2nm and zeta potential of -30.5 +/- 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates. [GRAPHICS]
引用
收藏
页码：1185 / 1195
页数：11
相关论文
共 50 条
  • [1] Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery
    Ramasamy, Thiruganesh
    Tuan Hiep Tran
    Choi, Ju Yeon
    Cho, Hyuk Jun
    Kim, Jeong Hwan
    Yong, Chul Soon
    Choi, Han-Gon
    Kim, Jong Oh
    CARBOHYDRATE POLYMERS, 2014, 102 : 653 - 661
  • [2] Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models
    Li, Feng
    Zhao, Xiao
    Wang, Hai
    Zhao, Ruifang
    Ji, Tianjiao
    Ren, He
    Anderson, Gregory J.
    Nie, Guangjun
    Hao, Jihui
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 12 (02) : 527 - 527
  • [3] Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models
    Li, Feng
    Zhao, Xiao
    Wang, Hai
    Zhao, Ruifang
    Ji, Tianjiao
    Ren, He
    Anderson, Gregory J.
    Nie, Guangjun
    Hao, Jihui
    ADVANCED FUNCTIONAL MATERIALS, 2015, 25 (05) : 788 - 798
  • [4] Improved oral delivery of tilianin through lipid-polymer hybrid nanoparticles to enhance bioavailability
    Zeng, Cheng
    Zheng, Ruifang
    Yang, Xiaoyi
    Du, Yanwen
    Xing, Jianguo
    Lan, Wei
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 519 (02) : 316 - 322
  • [5] Development of Sustained Release Baricitinib Loaded Lipid-Polymer Hybrid Nanoparticles with Improved Oral Bioavailability
    Anwer, Md. Khalid
    Ali, Essam A.
    Iqbal, Muzaffar
    Ahmed, Mohammed Muqtader
    Aldawsari, Mohammed F.
    Saqr, Ahmed Al
    Ansari, Mohd Nazam
    Aboudzadeh, M. Ali
    MOLECULES, 2022, 27 (01):
  • [6] Core Shell Lipid-Polymer Hybrid Nanoparticles for Oral Bioavailability Enhancement of Ibrutinib via Lymphatic Uptake
    Patel, Mitali
    Desai, Ayushi
    Kansara, Vrushti
    Vyas, Bhavin
    AAPS PHARMSCITECH, 2023, 24 (06)
  • [7] Core Shell Lipid-Polymer Hybrid Nanoparticles for Oral Bioavailability Enhancement of Ibrutinib via Lymphatic Uptake
    Mitali Patel
    Ayushi Desai
    Vrushti Kansara
    Bhavin Vyas
    AAPS PharmSciTech, 24
  • [8] Development of Lipid-Polymer Hybrid Nanoparticles for Improving Oral Absorption of Enoxaparin
    Tang, Bo
    Qian, Yu
    Fang, Guihua
    PHARMACEUTICS, 2020, 12 (07) : 1 - 11
  • [9] Lipid-Polymer Hybrid Nanoparticles for Oral Delivery of Tartary Buckwheat Flavonoids
    Zhang, Jinming
    Wang, Di
    Wu, Yihan
    Li, Wei
    Hu, Yichen
    Zhao, Gang
    Fu, Chaomei
    Fu, Shu
    Zou, Liang
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 66 (19) : 4923 - 4932
  • [10] Formulation, characterisation and comparison of different raloxifene hydrochloride loaded lipid-polymer hybrid nanoparticles
    Mahmood S.
    Phey T.C.
    Kheng L.S.
    Chen K.P.
    Mandal U.K.
    International Journal of Nano and Biomaterials, 2020, 9 (3-4) : 123 - 141
12345