Off-the-Shelf CAR-NK cells engineered to express calibrated release IL-15 exhibit enhanced persistence and anti-tumor activities

被引：0
|
作者：
Lee, Chen-Ting
Hung, Michelle
Banicki, Andrew
Song, Wenqi
Almudhfar, Niran
Kaveri, Deepika
Wong, Priscilla
Naitmazi, Lawrence
Guzman, Marcela
Lam, Alice
Yucel, Gozde
Lu, Timothy
Junca, Alba G.
Garrison, Brian
Lee, Philip
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-2902
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2902
引用
收藏
页数：2
相关论文
共 50 条
  • [1] CAR-NK cells from engineered pluripotent stem cells: Off-the-shelf therapeutics for all patients
    Lu, Shi-Jiang
    Feng, Qiang
    STEM CELLS TRANSLATIONAL MEDICINE, 2021, 10 : S10 - S17
  • [2] Cord Blood NK Cells Engineered to Express IL-15 and CD19-Targeted CAR Show Long-Term Persistence and Potent Anti-Tumor Activity
    Liu, Enli
    Tong, Yijiu
    Dotti, Gianpietro
    Savoldo, Barbara
    Mukherjee, Malini
    Orange, Jordan
    Shaim, Hila
    Lu, Xinyan
    Reynolds, Alexandra
    Gagea, Mihai
    Muftuoglu, Muharrem
    Li, Li
    Marin, David
    Wierda, William
    Keating, Michael
    Champlin, Richard
    Shpall, Elizabeth
    Rezvani, Katy
    MOLECULAR THERAPY, 2017, 25 (05) : 267 - 268
  • [3] Cord Blood NK Cells Engineered to Express a Humanized CD123-Targeted Chimeric Antigen Receptor (CAR) and IL-15 As Off-the-Shelf Therapy for Acute Myeloid Leukemia
    Kerbauy, Lucila Nassif
    Ang, Sonny
    Liu, Enli
    Banerjee, Pinaki P.
    Wu, Yewen
    Shaim, Hila
    Lim, Francesca Lorraine Wei Inng
    Basar, Rafet
    Li, Li
    Muftuoglu, Muharrem
    Daher, May
    Imahashi, Nobuhiko
    Mendt, Mayela Carolina
    Kaplan, Mecit
    Mukherjee, Malini
    Lee, Jessica C. H.
    Orange, Jordan S.
    Konopleva, Marina
    Andreeff, Michael
    Champlin, Richard E.
    Shpall, Elizabeth J.
    Rezvani, Katayoun
    BLOOD, 2017, 130
  • [4] Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
    Xuqing Zhang
    Mengyao Luo
    Shamael R. Dastagir
    Mellissa Nixon
    Annie Khamhoung
    Andrea Schmidt
    Albert Lee
    Naren Subbiah
    Douglas C. McLaughlin
    Christopher L. Moore
    Mary Gribble
    Nicholas Bayhi
    Viral Amin
    Ryan Pepi
    Sneha Pawar
    Timothy J. Lyford
    Vikram Soman
    Jennifer Mellen
    Christopher L. Carpenter
    Laurence A. Turka
    Thomas J. Wickham
    Tiffany F. Chen
    Nature Communications, 12
  • [5] Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
    Zhang, Xuqing
    Luo, Mengyao
    Dastagir, Shamael R.
    Nixon, Mellissa
    Khamhoung, Annie
    Schmidt, Andrea
    Lee, Albert
    Subbiah, Naren
    McLaughlin, Douglas C.
    Moore, Christopher L.
    Gribble, Mary
    Bayhi, Nicholas
    Amin, Viral
    Pepi, Ryan
    Pawar, Sneha
    Lyford, Timothy J.
    Soman, Vikram
    Mellen, Jennifer
    Carpenter, Christopher L.
    Turka, Laurence A.
    Wickham, Thomas J.
    Chen, Tiffany F.
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [6] Regulation of Cytokine Release and Anti-Tumor Effects of Expanded NK and CAR NK by ALT-803, an IL-15 Superagonist
    Chu, Yaya
    Hamby, Carl
    Misarti, Jesse
    Tesoriero, Jack
    Rosenblum, Jeremy
    Wong, Hing C.
    Lee, Dean A.
    Cairo, Mitchell S.
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S100 - S101
  • [7] Generation of Multiplexed Engineered, Off-the-Shelf CAR T Cells Uniformly Carrying Multiple Anti-Tumor Modalities to Prevent Tumor Relapse
    Chang, Chiawei
    Peralta, Eigen
    Hsia, Gloria
    Yang, Bi-Huei
    Yeh, Wen-I
    Clarke, Raedun
    Mili, Mandal
    Lee, Tom
    Pribadi, Mochtar
    Abujarour, Ramzey
    Lai, Yi-Shin
    Robbins, David
    Denholtz, Matthew
    Hanok, Sandeep Kothapally
    Driver, Emily
    Carron, Emily
    Navarrete, Natalie
    Sumi, May
    Mehta, Amit
    Chu, Philip
    ORourke, Jason
    Gutierrez, Alma
    Sung, Eric
    Gasparian, Suzanna
    Gentile, Angela
    Witty, Alec
    Yzaguirre, Amanda
    LaBarge, Samuel
    Nguyen, Cokey
    Valamehr, Bahram
    BLOOD, 2020, 136
  • [8] Off-the-Shelf, iPSC-Derived CAR-NK Cells Multiplexed-Engineered for the Avoidance of Allogeneic Host Immune Cell Rejection
    Mbofung, Rina M.
    Williams, Alan M.
    Hayama, Ken
    Pan, Yijia
    Groff, Brian
    Dailey, Thomas
    Reyes, Sonia
    Mahmood, Sajid
    Mathavan, Ketan
    Bonello, Greg
    Hammer, Quirin
    Malmberg, Karl-Johan
    Lee, Tom
    Bjordahl, Ryan
    Goodridge, Jode P.
    Valamehr, Bahram
    BLOOD, 2021, 138
  • [9] Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo
    Silvestre, Renata Nacasaki
    Eitler, Jiri
    de Azevedo, Julia Teixeira Cottas
    Tirapelle, Mariane Cariati
    Fantacini, Daianne Maciely Carvalho
    de Souza, Lucas Eduardo Botelho
    Swiech, Kamilla
    Covas, Dimas Tadeu
    Calado, Rodrigo T.
    Montero, Paola Ortiz
    Malmegrim, Kelen Cristina Ribeiro
    Figueiredo, Marxa L.
    Tonn, Torsten
    Picanco-Castro, Virginia
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [10] NKX019, AN OFF-THE-SHELF CD19 CAR-NK CELL, MEDIATES IMPROVED ANTI-TUMOR ACTIVITY AND PERSISTENCE IN COMBINATION WITH CD20-DIRECTED THERAPEUTIC MABS
    Tohme, Mira
    Davis, Tina
    Zhang, Max
    Lemar, Hadia
    Duong, Bao
    Tan, Joanne
    Trager, James
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A940 - A940
12345