Electrochemical sensor based on covalent organic framework loaded with FeCr2O4 nanoparticles for highly sensitive detection of amoxicillin

A novel electrochemical platform based on a covalent organic framework (COF) and FeCr2O4 nanoparticles was prepared for sensitive and selective detection of amoxicillin (AMX). The COF was synthesized with 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 2,5-Dimethoxybenzene-1,4-dicarboxaldehyde (DMTP) as precursors. The morphology and structure of the materials were characterized by scanning electron microscopy, Fourier transform spectroscopy, X-ray diffraction, and energy dispersive spectroscopy. Owing to the synergistic effect of the large surface area of TAPB-DMTP-COF material and the high catalytic capacity of FeCr2O4 nanoparticles, the sensor exhibits excellent analytical performance for AMX detection. Differential pulse voltammetry (DPV) experiments prove that the sensor owns a wide detection range (1 similar to 40 and 40 similar to 150 mu M) and low detection limit (0.3 mu M) for AMX. The sensor has good selectivity and reproducibility and also exhibits a good recovery rate in the actual sample analysis.