Estimating the influencing factors for T1b/T2 gallbladder cancer on survival and surgical approaches selection

被引：2

作者：

Cao, Jiasheng ^{[1
,2
]}

Yan, Jiafei ^{[1
,2
]}

Hu, Jiahao ^{[1
,2
]}

Zhang, Bin ^{[1
,2
]}

Topatana, Win ^{[2
]}

Li, Shijie ^{[1
,2
]}

Chen, Tianen ^{[1
,2
]}

Jeungpanich, Sarun ^{[2
]}

Lu, Ziyi ^{[2
]}

Peng, Shuyou ^{[1
,2
,3
]}

Cai, Xiujun ^{[1
,2
,4
]}

Chen, Mingyu ^{[1
,2
,4
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 16期

基金：

中国国家自然科学基金;

关键词：

gallbladder cancer; influencing factors; surgical approaches; survival; time to treatment; CT; EPIDEMIOLOGY; RESECTION; SURGERY; IMPACT; DELAY; TIME; US;

D O I：

10.1002/cam4.6297

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The influencing factors, especially time to treatment (TTT), for T1b/T2 gallbladder cancer (GBC) patients remain unknown. We aimed to identify the influencing factors on survival and surgical approaches selection for T1b/ T2 GBC.Methods: We retrospectively screened GBC patients between January 2011 and August 2018 from our hospital. Clinical variables, including patient characteristics, TTT, overall survival (OS), disease- free survival (DFS), surgery-related out-comes, and surgical approaches were collected.Results: A total of 114 T1b/T2 GBC patients who underwent radical resection were included. Based on the median TTT of 7.5 days, the study cohort was divided into short TTT group (TTT =7 days, n = 57) and long TTT group (TTT >7 days, n = 57). Referrals were identified as the primary factor prolonging TTT (p < 0.001). There was no significance in OS (p = 0.790), DFS (p = 0.580), and surgery-related outcomes (all p > 0.05) between both groups. Decreased referrals (p = 0.005), fewer positive lymph nodes (LNs; p = 0.004), and well tumor differentiation (p = 0.004) were all associated with better OS, while fewer positive LNs (p = 0.049) were associated with better DFS. Subgroup analyses revealed no significant dif-ference in survival between patients undergoing laparoscopic or open approach in different TTT groups (all p > 0.05). And secondary subgroup analyses found no significance in survival and surgery-related outcomes between different TTT groups of incidental GBC patients (all p > 0.05).Conclusions: Positive LNs and tumor differentiation were prognostic factors for T1b/T2 GBC survival. Referrals associating with poor OS would delay TTT, while the prolonged TTT would not impact survival, surgery-related outcomes, and surgical approaches decisions in T1b/T2 GBC patients.

引用

页码：16744 / 16755

页数：12