Transarterial Radioembolization Planning and Treatment with Microspheres Containing Holmium-166: Determination of Renal and Intestinal Radionuclide Elimination, Effective Half-Life, and Regulatory Aspects

被引：1

作者：

Kuehnel, Christian ^{[1
]}

Guehne, Falk ^{[1
]}

Seifert, Philipp ^{[1
]}

Freudenberg, Robert ^{[2
]}

Freesmeyer, Martin ^{[1
]}

Drescher, Robert ^{[1
]}

机构：

[1] Univ Hosp Jena, Clin Nucl Med, Klinikum 1, D-07747 Jena, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Nucl Med, D-01307 Dresden, Germany

来源：

CANCERS | 2023年 / 15卷 / 01期

关键词：

transarterial radioembolization; TARE; holmium-166; radioactivity excretion; radioactive waste; effective half-life;

D O I：

10.3390/cancers15010068

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Ho-166-based transarterial radioembolization (TARE) procedures for liver cancer treatment can be safely applied in a hospital setting. It has been shown that a fraction of the injected radioactivity is excreted. Knowledge of the amount and nature of these excretions is vital for dosimetry, radiation protection, record keeping, and compliance with national and international regulations regarding waste disposal. Radioprotection measures should be taken, with particular attention to the urine of patients after treatment procedures. Regulations regarding radioactive waste must be considered. After transarterial radioembolization (TARE) with microspheres loaded with holmium-166, radioactivity is excreted from the body. The aim of this study was to evaluate radioactive renal and intestinal excretions after TARE planning and treatment procedures with holmium-166-loaded microspheres and to correlate the findings with the intratherapeutic effective half-life. Urinary and intestinal excretions of patients who underwent TARE procedures were collected during postinterventional intervals of 24 h (TARE planning) and 48 h (TARE treatment). Whole-body effective half-life measurements were performed. Calibrations of the Ho-166 measuring system showed evidence of long-living nuclides. For excretion determination, 22 TARE planning procedures and 29 TARE treatment procedures were evaluated. Mean/maximum total excretion proportions of the injected Ho-166 were 0.0038%/0.0096% for TARE planning procedures and 0.0061%/0.0184% for TARE treatment procedures. The mean renal fractions of all measured excretions were 97.1% and 98.1%, respectively. Weak correlations were apparent between the injected and excreted activities (R-2 planning/treatment: 0.11/0.32). Mean effective Ho-166 half-lives of 24.03 h (planning) and 25.62 h (treatment) confirmed low excretions. Radioactive waste disposal regulations of selected jurisdictions can be met but must be reviewed before implementing this method into clinical practice. Inherent long-living nuclide impurities should be considered.

引用

页数：14