Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis

被引：13

作者：

Pei, Tingting ^{[1
]}

Hu, Rong ^{[1
]}

Wang, Fujing ^{[1
]}

Yang, Sixia ^{[1
]}

Feng, Haitong ^{[1
]}

Li, Qiye ^{[1
]}

Zhang, Jiaxing ^{[1
]}

Yan, Shihua ^{[1
]}

Ju, Liliang ^{[1
]}

He, Zhuoen ^{[1
]}

Han, Zhongxiao ^{[1
]}

Yang, Aicheng ^{[2
]}

Xiao, Wei ^{[1
,4
]}

Ma, Yun ^{[3
]}

Wang, Mingqing ^{[1
]}

机构：

[1] Southern Med Univ, Dept Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China

[2] Jinan Univ, Affiliated Jiangmen TCM Hosp, Nephropathy Ctr, Jiangmen 529030, Peoples R China

[3] Southern Med Univ, Nanfang Hosp, Dept Pharm, Guangzhou 510515, Guangdong, Peoples R China

[4] Guangdong Pharmaceut Univ, Key Lab Glucolipid Metab Disorder, Minist Educ, Guangzhou 510006, Guang Dong, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2023年 / 174卷

基金：

中国国家自然科学基金;

关键词：

Chronic kidney disease; Intestinal barrier; Akkermansia muciniphila; Intestinal microecology; Renal interstitial fibrosis; BLOOD-PRESSURE; HEART-FAILURE; CONTRIBUTES; DYSFUNCTION; MECHANISMS; SEQUENCES; RISK;

D O I：

10.1016/j.micpath.2022.105891

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Context: Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance of Akkermansia muciniphila (AKK) is significantly reduced in CKD patients.Objective: This study investigated the effects of AKK bacteria on kidney damage and the renal interstitium in rats with CKD.Materials and methods: CKD model 5/6 nephrectomy rats were used. CKD rats were supplemented with AKK (2 x 108 cfu/0.2 mL) for 8 weeks.Results: AKK administration significantly suppressed epithelial-mesenchymal transition (EMT), and highthroughput 16S rRNA pyrosequencing showed that AKK supplementation restored the disordered intestinal microecology in CKD rats. AKK also enhanced the intestinal mucosal barrier function. AKK may regulate the intestinal microecology and reduce renal interstitial fibrosis by enhancing the abundance of probiotics and reducing damage to the intestinal mucosal barrier.Conclusion: The results suggest that AKK administration could be a novel therapeutic strategy for treating renal fibrosis and CKD.

引用

页数：9