Case report: Gastric adenosquamous carcinoma with EBV-positive component of squamous cell carcinoma mixed with gastric carcinoma with lymphoid stroma: A novel case report and literature review

被引:0
|
作者
Lu, Chang [1 ]
Feng, Jizhen [2 ]
Yao, Zhigang [3 ]
Shi, Lei [4 ]
Li, Jiamei [3 ]
机构
[1] Shandong Univ, Shandong Prov Hosp, Dept Pathol, Jinan, Shandong, Peoples R China
[2] Shandong First Med Univ, Shandong Prov Hosp, Dept Radiol, Jinan, Shandong, Peoples R China
[3] Shandong First Med Univ, Shandong Prov Hosp, Dept Pathol, Jinan, Shandong, Peoples R China
[4] Shandong First Med Univ, Shandong Prov Hosp, Dept Gastroenterol, Jinan, Shandong, Peoples R China
关键词
case report; gastric cancer; Epstein-Barr virus; adenosquamous carcinoma; gastric carcinoma with lymphoid stroma; EPSTEIN-BARR-VIRUS;
D O I
10.3389/pore.2023.1610902
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Gastric adenosquamous carcinoma with EBV-positive component of squamous cell carcinoma mixed with gastric carcinoma with lymphoid stroma are extremely unusual variants of gastric carcinoma. We herein reported such a case and summarized five related cases that have been reported previously.Case presentation: A 59-year-old man was admitted to our hospital with upper abdominal discomfort and acid reflux. Gastric endoscopic examination revealed an irregular ulcer in the gastric angle. Biopsy of the lesion revealed adenocarcinoma. The patient underwent laparoscopic distal gastrectomy with lymph node dissection subsequently. Histologically, the tumor showed coexistence of GASC and GCLS. SCC and GCLS were positive for EBER in situ hybridization, while adenocarcinoma component was negative. Accordingly, the present case was diagnosed as GASC with EBV-positive component of SCC mixed with GCLS.Conclusion: GASC with EBV-positive component of SCC mixed with GCLS is extremely rare. Although the pathogenesis of GASC and the role of EBV in the development of an ASC component have not been fully elucidated, this case will help clinicians and pathologists better understand this special subtype of gastric tumor.
引用
收藏
页数:6
相关论文
共 50 条
  • [1] Simultaneous gastric adenosquamous carcinoma and gastric carcinoma with lymphoid stroma: A case report
    Miyake, Hirohiko
    Miyasaka, Mika
    Ishida, Mitsuaki
    Miki, Hirokazu
    Inoue, Kentarou
    Tsuta, Koji
    MOLECULAR AND CLINICAL ONCOLOGY, 2019, 11 (01) : 77 - 80
  • [2] Epstein–Barr virus-associated gastric adenosquamous carcinoma with concurrent gastric carcinoma with lymphoid stroma: a case report and review of the literature
    Fang Cao
    Yan Yan
    Dongfeng Niu
    Xiaozheng Huang
    Ling Jia
    Xinting Diao
    Zhongwu Li
    BMC Gastroenterology, 22
  • [3] Gastric Carcinoma with Lymphoid Stroma: A Rare Case Report with EBV Negativity
    Alqassim, E.
    Taherian, M.
    Huang, Y.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 154 : S49 - S50
  • [4] Epstein-Barr virus-associated gastric adenosquamous carcinoma with concurrent gastric carcinoma with lymphoid stroma: a case report and review of the literature
    Cao, Fang
    Yan, Yan
    Niu, Dongfeng
    Huang, Xiaozheng
    Jia, Ling
    Diao, Xinting
    Li, Zhongwu
    BMC GASTROENTEROLOGY, 2022, 22 (01)
  • [5] Primary gastric adenosquamous carcinoma: a case report and literature review
    Kan Jiang
    Xiaoyu Wu
    Baiying Liu
    Wenbin Li
    Taotao Zhang
    Xiangwen Zhang
    Changle Ren
    Guo Zu
    Oncology and Translational Medicine, 2019, 5 (04) : 188 - 191
  • [6] Gastric adenosquamous carcinoma: A case report
    Batur, S.
    Akpinar, R.
    Kepil, N.
    VIRCHOWS ARCHIV, 2019, 475 : S280 - S281
  • [7] Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report
    Cui, Yu-Jie
    Ren, Yan-Yan
    Zhang, Hong-Zhen
    WORLD JOURNAL OF CLINICAL CASES, 2022, 10 (25) : 8962 - 8967
  • [8] Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report
    Yu-Jie Cui
    Yan-Yan Ren
    Hong-Zhen Zhang
    World Journal of Clinical Cases, 2022, 10 (25) : 8962 - 8967
  • [9] Primary Gastric Adenosquamous Carcinoma: A Case Report
    Aly, Ragia
    Gupta, Sachin
    Gupta, Sorab
    Nagra, Navroop
    Goyal, Abhinav
    Singh, Balraj
    GASTROENTEROLOGY RESEARCH, 2020, 13 (04) : 155 - 157
  • [10] A primary gastric Adenosquamous carcinoma: Case report
    Alsheikh, Christine
    Aljammas, Abdullah Aladnan
    Nashar, Maan
    Alissa, Waad
    Aljarad, Ziad
    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2023, 106