Pioneer factor competing for fate change

被引：0
|
作者：
Yi, Rui [1 ]
Dou, Yali [2 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL USA
[2] Univ Southern Calif, Dept Med, Los Angeles, CA 90007 USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 08期
关键词：
D O I：
10.1038/s41556-023-01190-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pioneer transcription factors bind closed chromatin regions, alter local accessibility and activate target genes. A study reveals that the SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers via sequestration of epigenetic factors.
引用
收藏
页码：1081 / 1082
页数：2
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