The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition

被引：0

作者：

Felley-Bosco, Emanuela ^{[1
]}

Qi, Weihong ^{[2
,3
]}

Jean, Didier ^{[4
]}

Meiller, Clement ^{[4
]}

Rehrauer, Hubert ^{[2
,3
]}

机构：

[1] Univ Hosp Zurich, Dept Thorac Surg, Lab Mol Oncol, Sternwartstr 14, CH-8091 Zurich, Switzerland

[2] Swiss Fed Inst Technol, Funct Genom Ctr Zurich, CH-8057 Zurich, Switzerland

[3] Univ Zurich, CH-8057 Zurich, Switzerland

[4] Sorbonne Univ, Univ Paris Cite, Ctr Rech Cordeliers, Funct Genom Solid Tumors,Inserm, F-75006 Paris, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

pleural mesothelioma; RNA editing; epithelial-to-mesenchymal transition; CLASSIFICATION;

D O I：

10.3390/ijms24032874

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3 ' UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM.

引用

页数：8

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