Oxidative Cleavage of Csp3-Csp2 and Csp3-H Bonds with KOtBu: Highly Robust and Practical Synthesis of Diaryl/(het-Ar) Ketones

被引：4
|
作者：
Yaragorla, Srinivasarao [1 ]
Khan, Tabassum [1 ]
Behera, Ahalya [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 04期
关键词：
C-H OXIDATION; BENZYLIC OXIDATION; CATALYZED OXIDATION; EFFICIENT OXIDATION; SECONDARY ALCOHOLS; TERTIARY-AMINES; CARBON; HYDROXYLATION; COMPLEXES; ALKALOIDS;
D O I：
10.1021/acs.joc.2c02519
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report an efficient and practical approach for synthesizing diaryl(het) ketones from R-CO-CHR-Ar through a simultaneous oxidative cleavage of C-C and C-H bonds using KOtBu. This method enables synthesizing a variety of unsymmetrical and symmetrical (hetero)aryl ketones in excellent yields, which are otherwise difficult to make. Besides, we synthesized natural products using this method.
引用
收藏
页码：2103 / 2112
页数：10
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