A selective and mild electrochemical defluorinative carboxylation for late-stage C(sp3)-F bond functionalization

被引：8
|
作者：
Mondal, Subhojit [1 ]
Sarkar, Soumik [1 ]
Wang, Jason W. [1 ]
Meanwell, Michael W. [1 ]
机构：
[1] Univ Alberta, Dept Chem, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada
来源：
GREEN CHEMISTRY | 2023年 / 25卷 / 22期
基金：
加拿大自然科学与工程研究理事会;
关键词：
DEFLUOROALKYLATION; ACIDS;
D O I：
10.1039/d3gc03387b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the first general protocol for the electrochemical defluorinative carboxylation of trifluoromethyl (hetero)arenes, and trifluoromethyl-acetates and -acetamides, for accessing their highly valuable alpha,alpha-difluorocarboxylic acid analogues. Given the immense synthetic versatility of carboxylic acids, our new protocol may become a useful tool for accessing novel fluorinated analogues in drug design and agrochemical development.
引用
收藏
页码：9075 / 9079
页数：5
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