Double knock-down of both oncogenic ASPP proteins, iASPP and ASPP2kappa(k) results in strong, additive inhibition of proliferation in HER2+breast cancer models

被引：0
|
作者：
Hellwig, G. [1 ]
Beck, I [1 ]
Ahrens, A. L. [1 ]
Kampa-Schittenhelm, K. [1 ,2 ]
机构：
[1] Kantonsspital St Gallen, Med Onkol & Hamatol, St Gallen, Switzerland
[2] Univ Klinikum Tubingen, Innere Med Hamatol Onkol Klin Immunol & Rheumal 2, Tubingen, Germany
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2023年 / 46卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
V114
引用
收藏
页码：29 / 29
页数：1
相关论文
共 3 条
  • [1] Inhibition of oncogenic ASPP2kappa(k), a dominant-negative isoform of the tumorsuppressor ASPP2, results in reactivation of p53 in glioblastoma
    Hafner, Marlon
    Ruiba, Alessia
    Kampa, Leonie
    Kalin, Vincent
    Neidert, Marian
    Buchauer, Konrad
    Henke, Guido
    Plasswilm, Ludwig
    Schittenhelmn, Marcus M.
    Kampa-Schittenhelm, Kerstin M.
    CANCER RESEARCH, 2023, 83 (07)
  • [2] Specific Inhibition of oncogenic ASPP2kappa(k) by using Antibody-conjugated Nanoparticles Results in improved Response to Chemotherapy in HER2-positive breast Carcinoma Models
    Ruiba, A.
    Parra-Nieto, J.
    Beck, I
    Baeza, A.
    Schittenhelm, M.
    Kampa-Schittenhelm, K.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 105 - 106
  • [3] Expression of ASPP2k, a dominant-negative, oncogenic isoform of the Apoptosis-Stimulating Protein of p53-2 (ASPP2), accounts for a more aggressive tumorbiology in HER2+breast cancer
    Beck, I
    Ruiba, A.
    Sommer, I
    Aellig, V
    Ahrens, A. -L
    Kampa-Schittenhelm, K.
    ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 98 - 98
1