Five most important drug interactions in the critically ill

被引：0
|
作者：
Rychlickova, J. [1 ,2 ]
Suk, P. [1 ,3 ,4 ]
机构：
[1] Fak Nemocnice Sv Anny Brne, Int Clin Res Ctr, Brno, Czech Republic
[2] Masarykova Univ, Farmakol Ustav, Lekarska Fak, Brno, Czech Republic
[3] Masarykova Univ, Anesteziol Resuscitacni Klin, FN Sv Anny Brne Lekařska, Brno, Czech Republic
[4] Masarykova Univ, Lekarska Fak, Brno, Czech Republic
来源：
ANESTEZIOLOGIE A INTENZIVNI MEDICINA | 2023年 / 34卷 / 04期
关键词：
drug interactions; critical care; drug side effects; long QT syndrome; cytochrome P-450 enzyme enhibitors; QT INTERVAL PROLONGATION; VALPROIC ACID; TICAGRELOR PHARMACOKINETICS; INTENSIVE-CARE; DE-POINTES; QUETIAPINE; LEVODOPA; PHARMACODYNAMICS; KETOCONAZOLE; SAFETY;
D O I：
10.36290/aim.2023.053
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
The prevalence of drug interactions in the critically ill is high, but these are often potential drug interactions of limited clinical relevance. This paper aims to describe the mechanism and management of not the most frequent but, according to the authors, the most clinically significant interactions. These top five interactions include carbapenems and valproate, CYP 3A4 inhibitors and ticagrelor, enteral nutrition and levodopa, combinations of QT prolonging drugs, and CYP 3A4 inhibitors and quetiapine.
引用
收藏
页码：152 / 156
页数：5
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