The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of Vaccinology

被引：30

作者：

Ye, Zhongfeng ^{[1
]}

Harmon, Joseph ^{[1
]}

Ni, Wei ^{[2
]}

Li, Yamin ^{[3
]}

Wich, Douglas ^{[1
]}

Xu, Qiaobing ^{[1
]}

机构：

[1] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[2] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[3] SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY 13210 USA

来源：

ACS NANO | 2023年 / 17卷 / 16期

关键词：

mRNA vaccines; SARS-CoV-2; nonreplicating mRNA; self-amplifying mRNA; 5 & PRIME; cap; poly(A)tail; modified nucleosides; and 3 & PRIME; untranslated regions; lipid nanoparticles; TRANSFER-RIBONUCLEIC-ACID; CAP-BINDING PROTEIN; LIPID NANOPARTICLES; DENDRITIC CELLS; TRANSLATION INITIATION; IMMUNE-RESPONSES; IN-VITRO; T-CELL; COMBINATORIAL LIBRARY; CHEMICAL-MODIFICATION;

D O I：

10.1021/acsnano.2c12584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) technologies have been developed into high-performing and clinically viable vaccines against a range of infectious agents, notably SARS-CoV-2. mRNA vaccines demonstrate efficient in vivo delivery, long-lasting stability, and nonexistent risk of infection. The stability and translational efficiency of in vitro transcription (IVT)-mRNA can be further increased by modulating its structural elements. In this review, we present a comprehensive overview of the recent advances, key applications, and future challenges in the field of mRNA-based vaccinology.

引用

页码：15231 / 15253

页数：23

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