Fluorescent Sensors for Detecting and Imaging Metal Ions in Biological Systems: Recent Advances and Future Perspectives

被引:26
|
作者
Shi, Yang [1 ]
Zhang, Wenxian [1 ]
Xue, Yi [1 ]
Zhang, Jingjing [1 ,2 ]
机构
[1] Nanjing Univ, Sch Chem & Chem Engn, Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China
[2] Nanjing Univ, Chem & Biomed Innovat Ctr ChemB, Nanjing 210023, Peoples R China
基金
中国国家自然科学基金;
关键词
fluorescent sensors; metal ions; biosystems; detection; imaging; HIGHLY SELECTIVE DETECTION; GOLD NANOPARTICLE PROBE; TURN-ON DETECTION; CARBON DOTS; LIVING CELLS; IN-VITRO; NEURAL ACTIVITY; G-QUADRUPLEX; IRON-ION; DNA;
D O I
10.3390/chemosensors11040226
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Metal ions play a crucial role in many biochemical processes, and when in a state of scarcity or surplus, they can lead to various diseases. Therefore, the development of a selective, sensitive, cost-effective, and fast-responding sensor to detect metal ions is critical for in vitro medical diagnostics. In recent years, fluorescent sensors have been extensively investigated as potent kits for the effective assessment of metal ions in living systems due to their high sensitivity, selectivity, ability to perform real-time, non-invasive monitoring, and versatility. This review is an overview of recent advances in fluorescent sensors for the detection and imaging of metal ions in biosystems from 2018 to date. Specifically, we discuss their application in detecting essential metal ions and non-essential metal ions for in vitro diagnostics, living cell imaging, and in vivo imaging. Finally, we summarize remaining challenges and offer a future outlook on the above topics.
引用
收藏
页数:33
相关论文
共 50 条
  • [1] Fluorescent nanoprobes for sensing and imaging of metal ions: Recent advances and future perspectives
    Zhang, Jingling
    Cheng, FangFang
    Li, JingJing
    Zhu, Jun-Jie
    Lu, Yi
    NANO TODAY, 2016, 11 (03) : 309 - 329
  • [2] Fluorescent sensors for the detection of hydrazine in environmental and biological systems: Recent advances and future prospects
    Zhang, Xiang-Yang
    Yang, Yu-Shun
    Wang, Wei
    Jiao, Qing-Cai
    Zhu, Hai-Liang
    COORDINATION CHEMISTRY REVIEWS, 2020, 417
  • [3] Recent advances and perspectives in reaction-based fluorescent probes for imaging peroxynitrite in biological systems
    Cui, Wei-Long
    Wang, Mao-Hua
    Yang, Yun-Hao
    Wang, Jian-Yong
    Zhu, Xiuzhong
    Zhang, Haitao
    Ji, Xingxiang
    COORDINATION CHEMISTRY REVIEWS, 2023, 474
  • [4] Recent Advances in Nanocomposite Luminescent Metal-Organic Framework Sensors for Detecting Metal Ions
    Kanan, Sofian M.
    Malkawi, Ahmed
    COMMENTS ON INORGANIC CHEMISTRY, 2021, 41 (01) : 1 - 66
  • [5] PARAMAGNETIC METAL-IONS AS PROBES IN BIOLOGICAL-SYSTEMS - RECENT ADVANCES
    BERTINI, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1981, 182 (AUG): : 99 - &
  • [6] Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects
    Wang, Kai
    Wang, Wei
    Zhang, Xiang-Yang
    Jiang, Ai-Qin
    Yang, Yu-Shun
    Zhu, Hai-Liang
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2021, 136
  • [7] Fluorescent Sensors for Measuring Metal Ions in Living Systems
    Carter, Kyle P.
    Young, Alexandra M.
    Palmer, Amy E.
    CHEMICAL REVIEWS, 2014, 114 (08) : 4564 - 4601
  • [8] Recent Advances in Calixarene-Based Fluorescent Sensors for Biological Applications
    Marcos, Paula M.
    Berberan-Santos, Mario N.
    SENSORS, 2024, 24 (22)
  • [9] Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives
    Gao, Meng
    Tang, Ben Zhong
    ACS SENSORS, 2017, 2 (10): : 1382 - 1399
  • [10] Recent Advances in Photoacoustic Imaging: Current Status and Future Perspectives
    Liu, Huibin
    Teng, Xiangyu
    Yu, Shuxuan
    Yang, Wenguang
    Kong, Tiantian
    Liu, Tangying
    MICROMACHINES, 2024, 15 (08)