Mechanism of triterpenoids from Alismatis Rhizoma against liver fibrosis based on an integrated approach using network pharmacology, molecular docking, and luciferase assay

被引：0
|
作者：
Zhang, Yi [1 ,2 ,3 ]
Jiang, Kaiyuan [1 ,2 ]
Liu, Pei [1 ,2 ]
Tang, Yingying [1 ,2 ]
Li, Guancheng [4 ]
Xiong, Aizhen [1 ,2 ,3 ]
Yang, Li [1 ,2 ,3 ]
Wang, Zhengtao [1 ,2 ,3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chinese, Shanghai, Peoples R China
[3] Shanghai R&D Ctr Standardizat Tradit Chinese Med, Shanghai, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Peoples Hosp 6, Shanghai, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 22期
关键词：
Alismatis Rhizoma triterpenoids; liver fibrosis; network pharmacology; molecular docking; luciferase assay; farnesoid X receptor; ALISOL B 23-ACETATE; NONALCOHOLIC STEATOHEPATITIS; MEDIATED REGULATION; FXR; TRANSPORTERS; CHOLESTASIS; PROTECTS; ENZYMES; ACID; MICE;
D O I：
10.1080/14786419.2022.2149520
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Protostane-type triterpenoids are antifibrotic nature components with unique structures in Alismatis Rhizoma. However, the underlying mechanisms of them against liver fibrosis are not well illustrated. The present study aims to study the targets and mechanisms of Alismatis Rhizoma triterpenes responsible for their antifibrotic effects by network pharmacology, molecular docking, and luciferase assay. As a result, six molecular targets responsible for the antifibrotic effects of alisols against liver fibrosis were uncovered by network pharmacology, among which the activation of farnesoid X receptor (FXR/NR1H4) was highlighted and further confirmed by molecular docking and luciferase assay. Our present study provides a scientific basis for treating liver fibrosis by using Alismatis Rhizoma, especially via the FXR activation effects of alisols.
引用
收藏
页码：3826 / 3831
页数：6
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