Transcranial Direct Current Stimulation (tDCS) Effects on Quantitative Sensory Testing (QST) and Nociceptive Processing in Healthy Subjects: A Systematic Review and Meta-Analysis

被引:3
|
作者
Gurdiel-Alvarez, Francisco [1 ,2 ]
Gonzalez-Zamorano, Yeray [1 ,2 ,3 ,4 ]
Lerma-Lara, Sergio [5 ]
Gomez-Soriano, Julio [6 ]
Sanchez-Gonzalez, Juan Luis [7 ]
Fernandez-Carnero, Josue [2 ,3 ,8 ,9 ]
Navarro-Lopez, Victor [3 ,10 ]
机构
[1] Univ Rey Juan Carlos, Int Doctorate Sch, Dept Phys Therapy Occupat Therapy Rehabil & Phys M, Alcorcon 28933, Spain
[2] Rey Juan Carlos Univ, Fac Hlth Sci, Cognit Neurosci Pain & Rehabil Res Grp NECODOR, Madrid 28032, Spain
[3] Rey Juan Carlos Univ, Dept Phys Therapy Occupat Therapy Rehabil & Phys M, Madrid 28032, Spain
[4] Francisco De Vitoria Univ, Inst Life Sci, Brain Injury & Movement Disorders Neurorehabil Grp, Pozuelo De Alarcon 28223, Spain
[5] Ctr Super Estudios Univ Salle, Ctr Super Estudios Univ La Salle, Dept Phys Therapy, Madrid 28023, Spain
[6] Univ Castilla La Mancha, Fac Physiotherapy & Nursing, Toledo Physiotherapy Res Grp GIFTO, Toledo 45071, Spain
[7] Univ Salamanca, Fac Nursing & Physiotherapy, Dept Nursing & Physiotherapy, Inst Invest Biomed Salamanca IBSAL, Campus Miguel de Unamuno s-n, Salamanca 37007, Spain
[8] La Paz Hosp Inst Hlth Res, IdiPAZ, Madrid 28922, Spain
[9] Univ Europea Madrid, Fac Sport Sci, Musculoskeletal Pain & Motor Control Res Grp, Madrid 28670, Spain
[10] Rey Juan Carlos Univ, Fac Hlth Sci, Movement Anal Biomech Ergon & Motor Control Lab, Madrid 28922, Spain
关键词
transcranial direct current stimulation; central sensitization; healthy subjects; pain management; HUMAN MOTOR CORTEX; PAIN PERCEPTION; MODULATION; RESPONSES; THRESHOLDS; BRAIN;
D O I
10.3390/brainsci14010009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The aim of this study is to determine the effect that different tDCS protocols have on pain processing in healthy people, assessed using quantitative sensory tests (QST) and evoked pain intensity. Methods: We systematically searched in EMBASE, CINAHL, PubMed, PEDro, PsycInfo, and Web of Science. Articles on tDCS on a healthy population and regarding QST, such as pressure pain thresholds (PPT), heat pain thresholds (HPT), cold pain threshold (CPT), or evoked pain intensity were selected. Quality was analyzed using the Cochrane Risk of Bias Tool and PEDro scale. Results: Twenty-six RCTs were included in the qualitative analysis and sixteen in the meta-analysis. There were no significant differences in PPTs between tDCS and sham, but differences were observed when applying tDCS over S1 in PPTs compared to sham. Significant differences in CPTs were observed between tDCS and sham over DLPFC and differences in pain intensity were observed between tDCS and sham over M1. Non-significant effects were found for the effects of tDCS on HPTs. Conclusion: tDCS anodic over S1 stimulation increases PPTs, while a-tDCS over DLPFC affects CPTs. The HPTs with tDCS are worse. Finally, M1 a-tDCS seems to reduce evoked pain intensity in healthy subjects.
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页数:23
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