Regulation of HDAC11 gene expression in early myogenic differentiation

被引:1
|
作者
Li, Qiao [1 ,2 ,3 ]
Mach, Yan Z. [1 ]
Hamed, Munerah [1 ]
Khilji, Saadia [1 ]
Chen, Jihong [2 ,3 ]
机构
[1] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON, Canada
[2] Univ Ottawa, Fac Med, Dept Pathol, Ottawa, ON, Canada
[3] Univ Ottawa, Fac Med, Lab Med, Ottawa, ON, Canada
来源
PEERJ | 2023年 / 11卷
基金
加拿大自然科学与工程研究理事会;
关键词
Histone acetylation; Histone deacetylase; Gene regulation; Chromatin state; Myogenic differentiation; SKELETAL-MUSCLE; MYOD; CHROMATIN; P300; TRANSCRIPTION; BEXAROTENE; ENHANCERS; HATS;
D O I
10.7717/peerj.15961
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Histone acetylation and deacetylation affect the patterns of gene expression in cellular differentiation, playing pivotal roles in tissue development and maintenance. For example, the intrinsic histone acetyltransferase activity of transcriptional coactivator p300 is especially required for the expression of myogenic regulatory factors including Myf5 and MyoD, and consequently for skeletal myogenesis. On the other hand, histone deacetylases (HDACs) remove the acetyl group from histones, which is critical for gene repression in stem cell fate transition. Through integrative omic analyses, we found that while some HDACs were differentially expressed at the early stage of skeletal myoblast differentiation, Hdac11 gene expression was significantly enhanced by nuclear receptor signaling. In addition, p300 and MyoD control Hdac11 expression in milieu of normal and signal-enhanced myoblast differentiation. Thus, HDAC11 may be essential to differential gene expression at the onset of myoblast differentiation.
引用
收藏
页数:15
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