CD8+ T cell killing of MHC class I-deficient tumors

被引：1

作者：

Rudd, Christopher E. E. ^{[1
,2
,3
]}

机构：

[1] Univ Montreal, Dept Med, Montreal, PQ, Canada

[2] McGill Univ, Dept Med & Hlth Sci, Div Endocrinol & Metab, Montreal, PQ, Canada

[3] Hop Maisonneuve Rosemont CR HMR, Ctr Rech, Div Immunol Oncol, Montreal, PQ, Canada

来源：

NATURE CANCER | 2023年 / 4卷 / 09期

关键词：

D O I：

10.1038/s43018-023-00606-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD8(+) T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8(+) T cells eliminate cancer cells deficient in MHC class I has been unclear. A study now shows that adaptive CD8(+) T cell activation induces expression of the innate receptor NKG2D for the elimination of MHC class I-deficient tumors.

引用

页码：1214 / 1216

页数：3

共 50 条

[1] CD8+ T cell killing of MHC class I–deficient tumors
Christopher E. Rudd
Nature Cancer, 2023, 4 : 1214 - 1216
[2] Immunotherapy of MHC class I-deficient tumors
Reinis, Milan
FUTURE ONCOLOGY, 2010, 6 (10) : 1577 - 1589
[3] Persistence of memory CD8 T cells in MHC class I-deficient mice
Murali-Krishna, K
Lau, LL
Sambhara, S
Lemonnier, F
Altman, J
Ahmed, R
SCIENCE, 1999, 286 (5443) : 1377 - 1381
[4] Allospecific Rejection of MHC Class I-Deficient Bone Marrow by CD8 T Cells
Haspot, F.
Li, H. W.
Lucas, C. L.
Fehr, T.
Beyaz, S.
Sykes, M.
AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (01) : 49 - 58
[5] αβTCR+ cells are a minimal fraction of peripheral CD8+ pool in MHC class I-deficient mice
Nesic, D
Santori, FR
Vukmanovic, S
JOURNAL OF IMMUNOLOGY, 2000, 165 (04): : 1896 - 1901
[6] IFNγ producing CD8+ T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas
Buferne, Michel
Chasson, Lionel
Grange, Magali
Mas, Amandine
Arnoux, Fanny
Bertuzzi, Melanie
Naquet, Philippe
Leserman, Lee
Schmitt-Verhulst, Anne-Marie
Auphan-Anezin, Nathalie
ONCOIMMUNOLOGY, 2015, 4 (02): : 1 - 12
[7] MHC CLASS I-DEFICIENT MICE
RAULET, DH
ADVANCES IN IMMUNOLOGY, VOL 55, 1994, 55 : 381 - 421
[8] Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
Freland, S
Chambers, BJ
Andersson, M
Van Kaer, L
Ljunggren, HG
JOURNAL OF IMMUNOLOGY, 1998, 160 (02): : 572 - 579
[9] Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion
Tanaka, Y
Koido, S
Xia, JC
Ohana, M
Liu, CL
Cote, GM
Sawyer, DB
Calderwood, S
Gong, JL
JOURNAL OF IMMUNOLOGY, 2004, 172 (12): : 7848 - 7858
[10] Distinctive CD8+ T cell and MHC class I signatures in polycythemia vera patients
Cardoso, Elsa M.
Esgalhado, Andre J.
Patrao, Luis
Santos, Monica
Neves, Vasco Pinto
Martinez, Jorge
Vaz Patto, Maria Assuncao
Silva, Helena
Arosa, Fernando A.
ANNALS OF HEMATOLOGY, 2018, 97 (09) : 1563 - 1575

← 1 2 3 4 5 →