Association of IL-4 and IL-18 genetic polymorphisms with atopic dermatitis in Chinese children

被引:1
|
作者
Shi, Jianrong [1 ]
He, Lin [1 ]
Zheng, Huiwen [2 ]
Li, Wei [1 ]
Huang, Shuangshuang [1 ]
Li, Yunling [2 ]
Tao, Ran [1 ]
机构
[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Clin Lab,Sch Med, Hangzhou, Peoples R China
[2] Zhejiang Univ, Childrens Hosp, Dept Dermatol, Sch Med, Hangzhou, Peoples R China
来源
FRONTIERS IN PEDIATRICS | 2023年 / 11卷
关键词
interleukin-4; interleukin-18; atopic dermatitis; polymorphisms; susceptibility; inflammation; INTERLEUKIN-4; RECEPTOR; CELLS;
D O I
10.3389/fped.2023.1202100
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundAtopic dermatitis (AD) is a common chronic inflammatory skin disease, adversely affecting nearly 20% of the pediatric population worldwide. Interleukin-4 (IL-4) and interleukin-18 (IL-18) are considered to be involved in the pathogenesis and development of AD. The aim of this study was to investigate the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of AD in Chinese children. MethodsSix candidate single nucleotide polymorphisms (SNPs) in IL-4 and IL-18 genes were genotyped through multi-PCR combined with next-generation sequencing in 132 AD children and 100 healthy controls, and all the analyses were performed on blood genome DNA. ResultsThe frequencies of G allele, CG genotype and CG + GG genotype of IL-4 rs2243283, as well as the haplotype IL-4/GTT (rs2243283-rs2243250-rs2243248) were all significantly decreased in AD patients compared with the controls [G vs. C: P = 0.033, OR = 0.59; CG vs. CC: P = 0.024, OR = 0.47; CG + GG vs. CC: P = 0.012, OR = 0.49; GTT vs. CCT: P = 0.011, OR = 0.65]. Moreover, the frequencies of A allele, AA genotype and AG + AA genotype of IL-18 rs7106524, along with the haplotype IL-18/CAA (rs187238-rs360718-rs7106524) were statistically increased in the severe AD patients (A vs. G: P < 0.001, OR = 2.79; AA vs. GG: P = 0.003, OR = 5.51; AG + AA vs. GG: P = 0.036, OR = 2.93; CAA vs. CAG: P = 0.001, OR = 2.86). ConclusionsOur findings suggested that genetic variation in IL-4 rs2243283 such as G allele, CG genotype and CG + GG genotype might confer the reduced susceptibility to AD in Chinese children. Furthermore, A allele, AA genotype and AG + AA genotype of IL-18 rs7106524 explored the strong association with severity in Chinese AD children.
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页数:7
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