Denture Base Resin Coated with Titanium Dioxide (TiO2): A Systematic Review

Background: The main objective of this systematic review was to evaluate the effect of coating with titanium dioxide nanoparticles (TiO2 nanoparticle) on the surface condition of removable acrylic resin prosthetic base materials. Methods: Our review is registered in the PROSPERO database under the identification code CRD42023397170. Electronic database searches of PubMed, Scopus and Science Direct including studies from January 2009 to January 2023 were conducted and supplemented with manual searches. Research questions were generated in accordance with the PICO strategy. The modified Consolidated Standards of Reporting Trials (CONSORT) checklist was used to evaluate the quality of the selected studies. Results: Since the included studies were variable in design, a meta-analysis was not performed. The electronic searches retrieved 29 references that met the eligibility criteria, among which 5 studies matched the inclusion criteria for this review. Significant differences were detected between the TiO2 NP-coated and uncoated groups. The available data indicate that TiO2 NP coating elicits antimicrobial activity and improves the wear resistance of polymethylmethacrylate (PMMA) surfaces. Moreover, the nanoparticles provide high levels of glossiness and decelerate the process of color change of heat-cured acrylic resin, thus increasing the lifespan of dentures. Conclusion: The collective results clearly indicate that TiO2 nanoparticle coating induces alterations in the surface properties of pure PMMA, enhancing the mechanical, physical and biological characteristics of the denture base material. Further studies are essential to identify the optimal thickness of coating and concentrations of nanoparticles for clinical applications.