Clinical and Endoscopic Outcomes After Upadacitinib Induction for Ulcerative Colitis: A Multicenter Retrospective Cohort Study

被引：2
|
作者：
Dalal, Rahul S. [1 ]
Kallumkal, Govind [2 ]
Cabral, Heidy J. [1 ]
Bachour, Salam [3 ]
Barnes, Edward L. [4 ]
Allegretti, Jessica R. [1 ,5 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Gastroenterol Hepatol & Endoscopy, Boston, MA USA
[2] Univ North Carolina Chapel Hill, Dept Med, Chapel Hill, NC USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA
[4] Univ North Carolina Chapel Hill, Dept Med, Div Gastroenterol, Chapel Hill, NC USA
[5] 850 Boylston St,Suite 201, Chestnut Hill, MA 02467 USA
来源：
INFLAMMATORY BOWEL DISEASES | 2023年 / 30卷 / 07期
关键词：
inflammatory bowel disease; small molecule; biologic; safety; effectiveness; MAINTENANCE THERAPY;
D O I：
10.1093/ibd/izad155
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In this retrospective cohort study, upadacitinib induction was effective in achieving steroid-free clinical remission of ulcerative colitis for the majority of patients. Adverse events leading to treatment discontinuation were rare and were consistent with the known safety profile of upadacitinib.
引用
收藏
页码：1207 / 1210
页数：4
相关论文
共 50 条
  • [1] Real-World Clinical, Endoscopic, and Safety Outcomes After Upadacitinib Induction for Ulcerative Colitis: A Multicenter Retrospective Cohort Study
    Dalal, Rahul
    Kallumkal, Govind
    Cabral, Heidy
    Bachour, Salam
    Barnes, Edward
    Allegretti, Jessica R.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S850 - S851
  • [2] REAL-WORLD CLINICAL OUTCOMES OF UPADACITINIB FOR ULCERATIVE COLITIS AT 8-12 WEEKS: A MULTICENTER RETROSPECTIVE COHORT STUDY
    Dalal, Rahul S.
    Sninsky, Jared A.
    Radcliffe, Marlana
    Bachour, Salam
    Barnes, Edward L.
    McClure, Emma L.
    Allegretti, Jessica R.
    [J]. GASTROENTEROLOGY, 2023, 164 (06) : S1125 - S1125
  • [3] Comparative Effectiveness of Upadacitinib vs Ustekinumab for Ulcerative Colitis: A Multicenter Retrospective Cohort Study
    Dalal, Rahul S.
    Kallumkal, Govind
    Cabral, Heidy J.
    Bachour, Salam
    Barnes, Edward L.
    Allegretti, Jessica R.
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2024, 22 (03) : 666 - 668
  • [4] Comparative Effectiveness of Upadacitinib vs Ustekinumab for Ulcerative Colitis at 8-16 Weeks: A Multicenter Retrospective Cohort Study
    Dalal, Rahul
    Kallumkal, Govind
    Cabral, Heidy
    Bachour, Salam
    Barnes, Edward
    Allegretti, Jessica R.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S628 - S630
  • [5] Real-World Endoscopic and Histologic Outcomes in Ulcerative Colitis Patients: A Retrospective Cohort Study
    State, Monica
    Balanescu, Paul
    Voiosu, Theodor
    Bengus, Andreea
    Voiosu, Andrei
    Coman, Andrei
    Mustatea, Petronel
    Negreanu, Lucian
    Mateescu, Radu Bogdan
    Popp, Cristiana
    [J]. BIOMEDICINES, 2023, 11 (07)
  • [6] A multicenter, retrospective, observational study of the clinical outcomes and risk factors for relapse of ulcerative colitis at 1 year after leukocytapheresis
    Kobayashi, Taku
    Matsuoka, Katsuyoshi
    Yokoyama, Yoko
    Nakamura, Takashi
    Ino, Tomoko
    Numata, Toyoko
    Shibata, Hiroshi
    Aoki, Hirofumi
    Matsuno, Yoshihiro
    Hibi, Toshifumi
    [J]. JOURNAL OF GASTROENTEROLOGY, 2018, 53 (03) : 387 - 396
  • [7] A multicenter, retrospective, observational study of the clinical outcomes and risk factors for relapse of ulcerative colitis at 1 year after leukocytapheresis
    Taku Kobayashi
    Katsuyoshi Matsuoka
    Yoko Yokoyama
    Takashi Nakamura
    Tomoko Ino
    Toyoko Numata
    Hiroshi Shibata
    Hirofumi Aoki
    Yoshihiro Matsuno
    Toshifumi Hibi
    [J]. Journal of Gastroenterology, 2018, 53 : 387 - 396
  • [8] Intestinal Ultrasound to Assess Clinical Response After Induction With Upadacitinib in Acute Severe Ulcerative Colitis
    Shipley, Lindsey
    Russ, Kirk
    Zahid, Mohd
    Ismail, Mohamed
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (12S): : S10 - S10
  • [9] One-Year Comparative Effectiveness of Upadacitinib vs Tofacitinib for Ulcerative Colitis: A Multicenter Cohort Study
    Dalal, Rahul S.
    Kallumkal, Govind
    Cabral, Heidy J.
    Barnes, Edward L.
    Allegretti, Jessica R.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (08): : 1628 - 1631
  • [10] Clinical Outcomes of Endoscopic Submucosal Dissection for Colorectal Neoplasms: A Retrospective Multicenter Cohort Study
    Kuwai, Toshio
    Tanaka, Shinji
    Shigita, Kenjiro
    Matsuo, Taiji
    Terasaki, Motomi
    Nakadoi, Koichi
    Furudoi, Akira
    Hiraga, Yuko
    Kunihiro, Masaki
    Oka, Shiro
    Nagata, Shinji
    Chayama, Kazuaki
    [J]. GASTROINTESTINAL ENDOSCOPY, 2016, 83 (05) : AB229 - AB229
12345