Effects of β-caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction

被引:1
|
作者
Asth, Laila [1 ,2 ]
Cruz, Leonardo Cardoso [1 ]
Soyombo, Nicholas [1 ]
Rigo, Pedro [1 ]
Moreira, Fabricio A. [1 ]
机构
[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil
基金
巴西圣保罗研究基金会;
关键词
Cannabinoids; Cannabis; drugs; addiction; abuse; beta-caryophyllene; CB2; RECEPTORS; LOCALIZATION; AGONIST; BRAIN; TOXICITY; BEHAVIOR; REWARD; ALPHA;
D O I
10.2174/1570159X20666220927115811
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: beta-caryophyllene (BCP) is a natural bicyclic sesquiterpene found in Cannabis and other plants. BCP is currently used as a food additive, although pharmacological studies suggest its potential therapeutic application for the treatment of certain brain disorders. The mechanisms of action of BCP remain uncertain, possibly including full agonism at the cannabinoid CB2 receptor (CB2R). Objective: The study aims to investigate BCP's potential as a new drug for the treatment of substance use disorders by reviewing preclinical studies with animal models. Results: BCP has been investigated in behavioral paradigms, including drug self-administration, conditioned place preference, and intracranial self-stimulation; the drugs tested were cocaine, nicotine, alcohol, and methamphetamine. Remarkably, BCP prevented or reversed behavioral changes resulting from drug exposure. As expected, the mechanism of action entails CB2R activation, although this is unlikely to constitute the only molecular target to explain such effects. Another potential target is the peroxisome proliferator-activated receptor. Conclusion: Preclinical studies have reported promising results with BCP in animal models of substance use disorders. Further research, including studies in humans, are warranted to establish its therapeutic potential and its mechanisms of action.
引用
收藏
页码:213 / 218
页数:6
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