Blockade of PD-L1/CD80 Interactions Augments Function of Activated Donor T Cells Results in Augmenting Gvhd Induced By Donor Naive CD8+t Cells and GVL Effect Mediated By Donor Memory CD8+T Cells

被引：0
|
作者：
Song, Qingxiao [1 ]
Zhang, Yuankun [2 ]
Cassady, Kaniel [1 ,3 ]
Li, Qinjian [4 ]
Martin, Paul J. [5 ]
Zeng, Defu [2 ]
机构：
[1] City Hope Natl Med Ctr, Arthur D Riggs Diabet & Metab Res Inst, Beckman Res Inst, Duarte, CA USA
[2] Beckman Res Inst City Hope, Arthur Riggs Inst Diabet & Metab Res, Dept Immunol & Theranost, Duarte, CA USA
[3] Regeneron Pharmaceut, Tarrytown, NY USA
[4] City Hope Natl Comprehens Canc Ctr, Hematol Malignancies & Stem Cell Transplantat Ins, Duarte, CA USA
[5] Fred Hutchinson Canc Ctr, Seattle, WA USA
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-190733
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Tolerogenic dendritic cells impede priming of naive CD8+T cells and deplete memory CD8+T cells
    Kleijwegt, Fleur S.
    Jansen, Diahann T. S. L.
    Teeler, Josefine
    Joosten, Antoinette M.
    Laban, Sandra
    Nikolic, Tatjana
    Roep, Bart O.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (01) : 85 - 92
  • [2] Characterization of Melan-A reactive memory CD8+T cells in a healthy donor
    Voelter, Verena
    Rufer, Nathalie
    Reynard, Severine
    Greub, Gilbert
    Brookes, Roger
    Guillaume, Philippe
    Grosjean, Frederic
    Fagerberg, Theres
    Michelin, Olivier
    Rowland-Jones, Sarah
    Pinilla, Clemencia
    Leyvraz, Serge
    Romero, Pedro
    Appay, Victor
    INTERNATIONAL IMMUNOLOGY, 2008, 20 (08) : 1087 - 1096
  • [3] Blockade of PD-1 and LAG-3 expression on CD8+T cells promotes the tumoricidal effects of CD8+T cells
    Ma, Jiajia
    Yan, Shufang
    Zhao, Ying
    Yan, Huifang
    Zhang, Qian
    Li, Xinxia
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [4] CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells
    Rollins, Meagan R.
    Johnson, Rachel M. Gibbons
    JOURNAL OF IMMUNOLOGY RESEARCH, 2017, 2017
  • [5] PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells
    Ni, Xiong
    Song, Qingxiao
    Cassady, Kaniel
    Deng, Ruishu
    Jin, Hua
    Zhang, Mingfeng
    Dong, Haidong
    Forman, Stephen
    Martin, Paul J.
    Chen, Yuan-Zhong
    Wang, Jianmin
    Zeng, Defu
    JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (05): : 1960 - 1977
  • [6] Characterization of naive, memory and effector CD8+T cells: effect of age
    Gupta, S
    Bi, RF
    Su, K
    Yel, L
    Chiplunkar, S
    Gollapudi, S
    EXPERIMENTAL GERONTOLOGY, 2004, 39 (04) : 545 - 550
  • [7] Direct suppression of autoaggressive CD8+ T cells with CD80/86 blockade in CD8+T cell-mediated polymyositis models of mice
    Hasegawa, H.
    Kawahata, K.
    Mizoguchi, F.
    Okiyama, N.
    Miyasaka, N.
    Kohsaka, H.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2017, 35 (04) : 593 - 597
  • [8] Minimal activation of memory CD8+T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+T cells
    Belz, Gabrielle T.
    Bedoui, Sammy
    Kupresanin, Fiona
    Carbone, Francis R.
    Heath, William R.
    NATURE IMMUNOLOGY, 2007, 8 (10) : 1060 - 1066
  • [9] Exosomes derived from exhausted CD8+T cells impaired the anticancer function of normal CD8+T cells
    Wang, Xiaochen
    Shen, Haiyuan
    He, Qifeng
    Tian, Wenfang
    Xia, Anliang
    Lu, Xiao-Jie
    JOURNAL OF MEDICAL GENETICS, 2019, 56 (01) : 29 - 31
  • [10] Generation of effector CD8+T cells and their conversion to memory T cells
    Cui, Weiguo
    Kaech, Susan M.
    IMMUNOLOGICAL REVIEWS, 2010, 236 : 151 - 166
12345