Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties

被引:2
|
作者
He, Jiayu [1 ]
Liu, Yuandong [1 ]
Zeng, Xiaofeng [2 ,3 ]
Tong, Yan [1 ]
Liu, Run [1 ]
Wang, Kan [1 ]
Shangguan, Xiangdong [1 ]
Qiu, Guanzhou [1 ]
Sipaut, Coswald Stephen [3 ]
机构
[1] Cent South Univ, Sch Minerals Proc & Bioengn, Key Lab Biohydrometallurgy, Minist Educ, Changsha 410083, Peoples R China
[2] Hengyang Kaixin Special Mat Technol Co Ltd, Hengyang 421200, Peoples R China
[3] Univ Malaysia Sabah, Fac Engn, Kota Kinabalu 88400, Malaysia
关键词
silicon nitride; microwave sintering; mechanical properties; cytocompatibility; anti-bacteria; HIGH-STRENGTH; MICROSTRUCTURE; CERAMICS; BEHAVIOR; CELLS; BIOCOMPATIBILITY; PROLIFERATION; COMPOSITE; IMPLANTS; SURFACES;
D O I
10.3390/jfb14110552
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave-sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants.
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页数:16
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