Getting to the heart of thick-filament structure

被引:0
|
作者
Knight, Peter J. [1 ,2 ]
机构
[1] Univ Leeds, Fac Biol Sci, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, England
[2] Univ Leeds, Fac Biol Sci, Sch Mol & Cellular Biol, Leeds LS2 9JT, England
关键词
Structural biology; MYOSIN FILAMENT; PROTEIN; MODEL;
D O I
10.1038/d41586-023-03307-9
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure.
引用
收藏
页码:703 / 704
页数:2
相关论文
共 50 条
  • [1] Getting to the heart of thick-filament structure
    Peter J. Knight
    [J]. Nature, 2023, 623 : 703 - 704
  • [2] HYBRIDIZATION AND RECONSTITUTION OF THICK-FILAMENT STRUCTURE
    KORETZ, JF
    [J]. METHODS IN ENZYMOLOGY, 1982, 85 : 20 - 35
  • [3] Thick-Filament Extensibility in Intact Skeletal Muscle
    Ma, Weikang
    Gong, Henry
    Kiss, Balazs
    Lee, Eun-Jeong
    Granzier, Henk
    Irving, Thomas
    [J]. BIOPHYSICAL JOURNAL, 2018, 115 (08) : 1580 - 1588
  • [4] THICK-FILAMENT DEGENERATION ASSOCIATED WITH PERIARTERITIS-NODOSA
    HALPERIN, I
    KOBRIN, I
    ILSAR, M
    LUGASSY, G
    YAROM, R
    [J]. ARCHIVES OF NEUROLOGY, 1982, 39 (11) : 730 - 732
  • [5] Stretch Reduces Interfilament Spacing And Triggers Alterations In Thick-filament Structure In Healthy Left-atrial Fibers
    Ma, Weikang
    Papadaki, Maria
    Kirk, Jonathan A.
    Rupert, Cassady
    del Rio, Carlos L.
    Irving, Thomas C.
    [J]. CIRCULATION RESEARCH, 2022, 131
  • [6] CARDIAC THICK-FILAMENT STRUCTURAL AND FUNCTIONAL CHANGES CONTRIBUTE TO CIRRHOTIC CARDIOMYOPATHY IN RATS
    Liu, H.
    Honar, H.
    Glenn, T.
    ter Keurs, H. E. D. J.
    Lee, S. S.
    [J]. JOURNAL OF HEPATOLOGY, 2013, 58 : S240 - S240
  • [7] Decoupling calcium-dependent thin-filament activation from thick-filament activation in porcine myocardium
    Mohran, Saffie
    Mandrycky, Christian
    Tu, An-Yue
    McMillen, Tim
    Kooiker, Kristina B.
    Qian, Wenjing
    Irving, Thomas C.
    Regnier, Michael
    Ma, Weikang
    [J]. BIOPHYSICAL JOURNAL, 2024, 123 (03) : 520A - 520A
  • [8] Modeling mechanisms of the thick-filament off-state dynamics in cardiac muscle
    Lewalle, Alexandre
    Milburn, Gregory
    Campbell, Kenneth S.
    Niederer, Steven A.
    [J]. BIOPHYSICAL JOURNAL, 2023, 122 (03) : 384A - 384A
  • [9] Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins
    Ait-Mou, Younss
    Hsu, Karen
    Farman, Gerrie P.
    Kumar, Mohit
    Greaser, Marion L.
    Irving, Thomas C.
    de Tombe, Pieter P.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (08) : 2306 - 2311
  • [10] Direct Evidence for the Effect of Titin Stiffness on Thick-Filament Mechanical Properties in Stretched Muscle Sarcomeres
    Li, Yong
    Linke, Wolfgang A.
    [J]. BIOPHYSICAL JOURNAL, 2015, 108 (02) : 591A - 591A