Miniaturized Neural Observation System for in vivo Brain Imaging in Freely Moving Rats

被引：0

作者：

Siwadamrongpong, Ronnakorn ^{[1
]}

Sunaga, Yoshinori ^{[1
]}

Sasagawa, Kiyotaka ^{[1
]}

Ohta, Yasumi ^{[1
]}

Takehara, Hironari ^{[1
]}

Haruta, Makito ^{[1
,2
]}

Tashiro, Hiroyuki ^{[1
,3
]}

Ohta, Jun ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Sci & Technol, Div Mat Sci, 8916-5 Takayama, Ikoma, Nara 6300192, Japan

[2] Chitose Inst Sci & Technol, Fac Sci & Engn, Dept Optoelect Syst Engn, 75865 Bibi, Chitose, Hokkaido 0668655, Japan

[3] Kyushu Univ, Fac Med Sci, Dept Hlth Sci, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

来源：

SENSORS AND MATERIALS | 2023年 / 35卷 / 09期

关键词：

CMOS image sensor; implantable device; brain surface imaging; in vivo imaging; DEVICE; SENSOR;

D O I：

10.18494/SAM4563

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

In this study, we developed a miniaturized observation system for rat brain imaging using an implantable imager. A small data-acquisition device was designed to be mounted on the back of an adult rat, reducing the disturbance to the output of the imager caused by a long cable. With a weight of approximately 6.8 g, the movement of adult rats with an average weight of 200 g was unrestricted. The readout characteristics were evaluated at the light level. The in vivo experiments were performed using mice and freely moving rats. Using the developed data analysis pipeline, blood flow in the vessels was observed.

引用

页码：3227 / 3239

页数：13

共 50 条

[1] Extendable, miniaturized multi-modal optical imaging system: cortical hemodynamic observation in freely moving animals
Liu, Rui
Huang, Qin
Li, Bing
Yin, Cui
Jiang, Chao
Wang, Jia
Lu, Jinling
Luo, Qingmin
Li, Pengcheng
[J]. OPTICS EXPRESS, 2013, 21 (02): : 1911 - 1924
[2] Assessment of Brain Functional Activity Using a Miniaturized Head-Mounted Scanning Photoacoustic Imaging System in Awake and Freely Moving Rats
Wang, Yuhling
Chu, Tsung-Sheng
Lin, Yan-Ren
Tsao, Chia-Hui
Tsai, Chia-Hua
Ger, Tzong-Rong
Chen, Li-Tzong
Chang, Wun-Shaing Wayne
Liao, Lun-De
[J]. BIOSENSORS-BASEL, 2021, 11 (11):
[3] Assessment of brain functional activity using a miniaturized head-mounted scanning photoacoustic imaging system in awake and freely moving rats
Wang, Yuhling
Chu, Tsung-Sheng
Lin, Yan-Ren
Tsao, Chia-Hui
Tsai, Chia-Hua
Ger, Tzong-Rong
Chen, Li-Tzong
Chang, Wun-Shaing Wayne
Liao, Lun-De
[J]. Biosensors, 2021, 11 (11):
[4] Advances of optical miniscopes for in vivo imaging of neural activity in freely moving animals
Chen, Kunpeng
Tian, Zhaoshi
Kong, Lingjie
[J]. FRONTIERS IN NEUROSCIENCE, 2022, 16
[5] PET imaging of freely moving interacting rats
Miranda, Alan
Kang, Min Su
Blinder, Stephan
Bouhachi, Reda
Soucy, Jean-Paul
Aliaga-Aliaga, Arturo
Massarweh, Gassan
Stroobants, Sigrid
Staelens, Steven
Rosa-Neto, Pedro
Verhaeghe, Jeroen
[J]. NEUROIMAGE, 2019, 191 : 560 - 567
[6] Miniaturized wireless calcium recording system for freely moving mice
Suzuki, Takayuki
Kamoshida, Atsushi
Homma, Chihiro
Yamada, Kazuyuki
Mizunaka, Masaru
Arai, Kenichi
Larkum, Matthew E.
Miyawaki, Atsushi
Murayama, Masanori
[J]. JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, 63 : S289 - S289
[7] In vivo validation of a new portable stimulator for chronic deep brain stimulation in freely moving rats
Tibar, Houyam
Naudet, Frederic
Kolbl, Florian
Ribot, Bastien
Faggiani, Emilie
N'Kaoua, Gilles
Renaud, Sylvie
Lewis, Noelle
Benazzouz, Abdelhamid
[J]. JOURNAL OF NEUROSCIENCE METHODS, 2020, 333
[8] Fluconazole distribution to the brain: A crossover study in freely-moving rats using in vivo microdialysis
Yang, H
Wang, Q
Elmquist, WF
[J]. PHARMACEUTICAL RESEARCH, 1996, 13 (10) : 1570 - 1575
[9] ANALYSIS AND MICRODIALYSIS OF ACETYLCHOLINE IN THE BRAIN OF FREELY MOVING RATS
DAMSMA, G
WESTERINK, BHC
DEVRIES, JB
HORN, AS
[J]. PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1987, 9 (06) : 338 - 338
[10] A Fiber Optic Multi-Channel Neural Recording System for Freely Moving Rats
Park, Sunmee
Ozden, Ilker
Song, Y. K.
Yin, Ming
Nurmikko, Arto V.
[J]. 2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER), 2013, : 1287 - 1290

← 1 2 3 4 5 →