Toll-like receptor 4: A potential therapeutic target for multiple human diseases

被引：19
|
作者：
Wei, Jinrui [1 ,2 ,3 ]
Zhang, Yan [1 ,2 ,3 ]
Li, Haopeng [1 ,2 ,3 ]
Wang, Fuquan [1 ,2 ,3 ]
Yao, Shanglong [1 ,2 ,3 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Inst Anesthesia & Crit Care Med, Tongji Med Coll, Wuhan 430022, Peoples R China
[3] Huazhong Univ Sci & Technol, Key Lab Anesthesiol & Resuscitat, Minist Educ, Hongshan, Peoples R China
[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Anesthesiol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 166卷
关键词：
Immune response; Toll -like receptor 4; Cardiovascular; Neoplastic; Inflammatory; NF-KAPPA-B; ESOPHAGEAL CANCER-CELLS; TRAUMATIC BRAIN-INJURY; NLRP3; INFLAMMASOME; REGULATORY FACTOR-3; ADHESION MOLECULES; SIGNALING PATHWAYS; ACTIVATION; TLR4; LIPOPOLYSACCHARIDE;
D O I：
10.1016/j.biopha.2023.115338
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor 4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its dysregulation significantly contributes to the onset of various diseases, encompassing cardiovascular disorders, neoplastic conditions, and inflammatory ailments. This comprehensive review centers on elucidating the architectural and distributive characteristics of TLR4, its conventional signaling pathways, and its mode of action in diverse disease contexts. Ultimately, this review aims to propose novel avenues and therapeutic targets for clinical intervention.
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页数：9
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