Protecting Group-Free Gold-Catalyzed Synthesis of 2-Acylidene-3-Oxindoles and Azaaurones via a Double Oxidation Strategy

被引：3
|
作者：
Song, Xinlong [1 ]
Zhao, Ximei [1 ]
Zeng, Zhongyi [1 ]
Rominger, Frank [1 ]
Rudolph, Matthias [1 ]
Hashmi, A. Stephen K. [1 ]
机构：
[1] Heidelberg Univ, Organ Chem Inst, Neuenheimer Feld 270, D-69120 Heidelberg, Germany
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2023年 / 63卷 / 09期
关键词：
oxidative gold catalysis; N-oxides; one pot synthesis; gold carbene intermediates; alkynes; INDUSTRIAL PERSPECTIVE; COUNTER ANIONS;
D O I：
10.1002/ijch.202300094
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthesis of 2-acylidene-3-oxindole and azaaurone derivatives starting from O-alkynylanilines and alkynes is presented. By means of oxidative gold catalysis the two starting materials are transferred to reactive intermediates that in situ form the target products. This double oxidation strategy enables a protecting group-free step-economic strategy towards these valuable substrate classes.
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页数：7
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