Navigating the Evolving Treatment Landscape of Diffuse Large B-Cell Lymphoma

被引：23
|
作者：
Nastoupil, Loretta J. [1 ,3 ]
Bartlett, Nancy L. [2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX USA
[2] Washington Univ, Siteman Canc Ctr, St Louis, MO USA
[3] Univ Texas MD Anderson Canc Ctr, 1515 Holcombe Blvd,Unit 429, Houston, TX 77030 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 41卷 / 04期
关键词：
RITUXIMAB PLUS CYCLOPHOSPHAMIDE; PREVIOUSLY UNTREATED PATIENTS; SOUTHWEST-ONCOLOGY-GROUP; NON-HODGKIN-LYMPHOMA; DOUBLE-HIT LYMPHOMA; SINGLE-ARM; OPEN-LABEL; ELDERLY-PATIENTS; PHASE-III; R-CHOP;
D O I：
10.1200/JCO.22.01848
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma, comprises a heterogenous group of morphologically, genetically, and clinically distinct diseases. Several recent advances have affected the treatment landscape, which had been mostly stagnant for the past few decades. We will review the practice-changing studies in frontline (POLARIX), early relapse (ZUMA-7 and TRANSFORM), and multiple recurrent (ZUMA-1, JULIET, TRANSCEND, L-MIND, and LOTIS-2) stages and discuss how the treatment landscape may evolve with the emergence of bispecific antibodies.
引用
收藏
页码：903 / +
页数：12
相关论文
共 50 条
  • [1] Evolving therapeutic landscape of diffuse large B-cell lymphoma: challenges and aspirations
    Chan, Jason Yongsheng
    Somasundaram, Nagavalli
    Grigoropoulos, Nicholas
    Lim, Francesca
    Poon, Michelle Limei
    Jeyasekharan, Anand
    Yeoh, Kheng Wei
    Tan, Daryl
    Lenz, Georg
    Ong, Choon Kiat
    Lim, Soon Thye
    DISCOVER ONCOLOGY, 2023, 14 (01)
  • [2] Evolving therapeutic landscape of diffuse large B-cell lymphoma: challenges and aspirations
    Jason Yongsheng Chan
    Nagavalli Somasundaram
    Nicholas Grigoropoulos
    Francesca Lim
    Michelle Limei Poon
    Anand Jeyasekharan
    Kheng Wei Yeoh
    Daryl Tan
    Georg Lenz
    Choon Kiat Ong
    Soon Thye Lim
    Discover Oncology, 14
  • [3] The Genetic Landscape of Diffuse Large B-Cell Lymphoma
    Pasqualucci, Laura
    Dalla-Favera, Riccardo
    SEMINARS IN HEMATOLOGY, 2015, 52 (02) : 67 - 76
  • [4] Evolving Treatment Paradigms for Primary Mediastinal Diffuse Large B-Cell Lymphoma
    Hamlin, Paul A.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (17) : 1751 - 1753
  • [5] Treatment of diffuse large B-cell lymphoma
    Gleissner, B.
    Zwick, C.
    Pfreundschuh, M.
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2008, 133 (36) : 1785 - 1794
  • [6] Treatment of Diffuse Large B-Cell Lymphoma
    Miyazaki, Kana
    JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2016, 56 (02) : 79 - 88
  • [7] Diffuse large B-cell lymphoma - Molecular heterogeneity of diffuse large B-cell lymphoma
    Gascoyne, RD
    HEMATOLOGY JOURNAL, 2004, 5 : S144 - S148
  • [8] The Evolving Role of Bispecific Antibodies in Diffuse Large B-Cell Lymphoma
    Saleh, Khalil
    Khoury, Rita
    Khalife, Nadine
    Chahine, Claude
    Ibrahim, Rebecca
    Tikriti, Zamzam
    Le Cesne, Axel
    JOURNAL OF PERSONALIZED MEDICINE, 2024, 14 (07):
  • [9] Pidilizumab in the treatment of diffuse large B-cell lymphoma
    Bryan, Locke J.
    Gordon, Leo I.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (09) : 1361 - 1368
  • [10] Treatment resistance in diffuse large B-cell lymphoma
    He, Michael Y.
    Kridel, Robert
    LEUKEMIA, 2021, 35 (08) : 2151 - 2165
12345