RROL lncRNA role in multiple myeloma

被引：3
|
作者：
Agirre, Xabier [1 ,2 ]
机构：
[1] Univ Navarra, Pamplona, Spain
[2] Ctr Invest Biomed Canc, Madrid, Spain
来源：
BLOOD | 2023年 / 141卷 / 04期
关键词：
D O I：
10.1182/blood.2022018471
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Morelli et al1 show that the novel long noncoding RNA (lncRNA) named RROL (RNA Regulator of Lipogenesis), derived from the MIR17HG gene, acts as a chromatin scaffold for protein interaction that results in the growth of multiple myeloma cells. Their study shows that RROL inhibition exhibits a potent antimyeloma activity both in vitro and in different in vivo models, suggesting a therapeutic potential.
引用
收藏
页码：328 / 330
页数：3
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