Grape seed extract improves intestinal barrier integrity and performance: Evidence from in vitro, Caenorhabditis elegans and Drosophila melanogaster experiments and a study with growing broilers

被引：3

作者：

Sandner, Georg ^{[1
,2
]}

Stadlbauer, Verena ^{[1
,2
]}

Sadova, Nadiia ^{[1
]}

Neuhauser, Cathrina ^{[1
]}

Schwarzinger, Bettina ^{[1
,2
]}

Karlsberger, Lea ^{[1
,2
]}

Hangweirer, Kerstin ^{[2
]}

Antensteiner, Katharina ^{[1
]}

Stallinger, Alexander ^{[3
]}

Aumiller, Tobias ^{[3
]}

Weghuber, Julian ^{[1
,2
]}

机构：

[1] Univ Appl Sci Upper Austria, Ctr Excellence Food Technol & Nutr, Stelzhamerstr 23, A-4600 Wels, Austria

[2] FFoQSI GmbH, Austrian Competence Ctr Feed & Food Qual Safety &, Technopark 1D, A-3430 Tulln, Austria

[3] Delacon Biotech GmbH, Langwiesen 24, A-4209 Engerwitzdorf, Austria

来源：

FOOD BIOSCIENCE | 2023年 / 52卷

关键词：

Intestinal functionality; Intestinal barrier; Grape seed extract; C; elegans; D; melanogaster; Broiler; Oxidative stress; OXIDATIVE STRESS; PROANTHOCYANIDIN EXTRACT; GROWTH-PERFORMANCE; PROCYANIDINS; POLYPHENOLS; FLAVAN-3-OLS; INFLAMMATION; RESISTANCE; MARKERS; HEALTH;

D O I：

10.1016/j.fbio.2023.102483

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Grape seed extract (GSE) is an interesting source for polyphenols and other phytochemicals with high antioxidant potential. Here, we report on a comprehensive study investigating GSE in various in vitro and in vivo experiments. Obtained results indicate that GSE improves parameters related to intestinal barrier integrity in cell culture, C. elegans and D. melanogaster. Faster wound healing was observed in a scratch assay using intestinal IPEC-J2 cells when pre-treated with GSE. Furthermore, reactive oxygen species were found to be significantly decreased in cell culture and C. elegans experiments. In C. elegans, qPCR gene expression analysis revealed sig-nificant modulations after 24 h of GSE treatment. Finally, a 42-day broiler feeding study revealed a dose dependant effect on growth performance in the GSE supplemented groups. In conclusion, GSE was found to provide promising properties including wound closure, intestinal integrity, and antioxidant activity.

引用

页数：9

共 2 条

[1] Grape seed extract improves intestinal barrier integrity and increases lifespan in various model systems
Sadova, N.
Sandner, G.
Stadlbauer, V.
Neuhauser, C.
Antensteiner, K.
Hangweirer, K.
Karlsberger, L.
Schwarzinger, B.
Weghuber, J.
FEBS OPEN BIO, 2022, 12 : 55 - 56
[2] Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers
Sandner, Georg
Mueller, Andreas S.
Zhou, Xiaodan
Stadlbauer, Verena
Schwarzinger, Bettina
Schwarzinger, Clemens
Wenzel, Uwe
Maenner, Klaus
van der Klis, Jan Dirk
Hirtenlehner, Stefan
Aumiller, Tobias
Weghuber, Julian
MOLECULES, 2020, 25 (04):

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