The Choice of the Most Appropriate Suture Threads for Pancreatic Anastomoses on the Basis of Their Mechanical Characteristics

被引：1

作者：

Pagnanelli, Michele ^{[1
,2
]}

De Gaetano, Francesco ^{[3
]}

Nappo, Gennaro ^{[1
,2
]}

Capretti, Giovanni ^{[1
,2
]}

Costantino, Maria Laura ^{[3
]}

Zerbi, Alessandro ^{[1
,2
]}

机构：

[1] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Milan, Italy

[2] IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Milan, Italy

[3] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, I-20133 Milan, Italy

来源：

BIOMEDICINES | 2023年 / 11卷 / 04期

关键词：

pancreaticoduodenectomy; pancreatic anastomoses; pancreatic fistula; suture material; Polydioxanone; Poliglecaprone; 25; TENSILE-STRENGTH; IN-VITRO; FISTULA; PANCREATICODUODENECTOMY; PANCREATICOJEJUNOSTOMY; PH; RECONSTRUCTION; DRAINAGE; STENT; PANCREATICOGASTROSTOMY;

D O I：

10.3390/biomedicines11041055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The choice of the most appropriate suture threads for pancreatic anastomoses may play an important role in reducing the incidence of post-operative pancreatic fistula (POPF). The literature on this topic is still not conclusive. The aim of this study was to analyze the mechanical characteristics of suture materials to find the best suture threads for pancreatic anastomoses. A single-axial electromagnetic actuation machine was used to obtain the stress-deformation relationship curves and to measure both the ultimate tensile strength (UTS) and the Young's modulus at the 0-3% deformation range (E0-3) of four different suture materials (Poliglecaprone 25, Polydioxanone, Polyglactin 910, and Polypropylene) at baseline and after incubation in saline solution, bile, and pancreatic juice for 1, 3, and 7 days. Polydioxanone and Polypropylene showed stable values of UTS and E0-3 in all conditions. Polyglactin 910 presented significant UTS and E0-3 variations between different time intervals in all types of liquids analyzed. Poliglecaprone 25 lost half of its strength in all biological liquids analyzed but maintained low E0-3 values, which could reduce the risk of lacerations of soft tissues. These results suggest that Polydioxanone and Poliglecaprone 25 could be the best suture materials to use for pancreatic anastomoses. In vivo experiments will be organized to obtain further confirmations of this in vitro evidence.

引用

页数：17