Autophagy Modulation and Its Implications on Glioblastoma Treatment

被引:4
|
作者
Chen, Johnny [1 ]
Rodriguez, Andrea Salinas [2 ]
Morales, Maximiliano Arath [3 ]
Fang, Xiaoqian [1 ]
机构
[1] Univ Texas Rio Grande Valley, Sch Med, Dept Neurosci, Edinburg, TX 78539 USA
[2] Univ Texas Rio Grande Valley, Dept Hlth & Biomed Sci, Edinburg, TX 78539 USA
[3] Univ Texas Rio Grande Valley, Coll Sci, Dept Biol, Edinburg, TX 78539 USA
关键词
autophagy; glioblastoma; treatment; JAK2/STAT3 signaling pathway; PI3K/AKT/mTOR signaling pathway; CHAPERONE-MEDIATED AUTOPHAGY; TEMOZOLOMIDE RESISTANCE; DEPENDENT APOPTOSIS; INHIBITS AUTOPHAGY; ALPHA-SYNUCLEIN; BREAST-CANCER; DNA-DAMAGE; CELLS; PI3K/AKT/MTOR; PATHWAY;
D O I
10.3390/cimb45110546
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted.
引用
收藏
页码:8687 / 8703
页数:17
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