Synthesis and cytotoxic activity of new hexaazadibenzotetracenes derived from trans-1,2-diaminocyclohexane

被引：2
|
作者：
Rakhimova, Elena B. [1 ]
Kirsanov, Victor Yu. [1 ]
Kuzmina, Ulyana Sh. [2 ]
Galyautdinov, Ilgiz V. [2 ]
Vakhitova, Yulia V. [2 ]
机构：
[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, Ufa 450075, Russia
[2] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa 450054, Russia
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 01期
关键词：
catalysis; heterocyclization; trans-1; 2-diaminocyclohexane; anilines; polycyclic compounds; hexaazadibenzotetracenes; cytotoxic activity; ENANTIOSELECTIVE MICHAEL ADDITIONS; 1,3-DICARBONYL COMPOUNDS; ACIDS;
D O I：
10.1016/j.mencom.2023.01.035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot synthesis of N,N'-disubstituted (3bR*,7aR*,1 0bR*,14aR*)-octadecahydro-1H,8H- 2,3a,7b,9,10a,14b-hexaazadibenzo[fg, op]tetracenes via the catalytic heterocyclization of trans-1,6,7,12-tetraaza-perhydrotetracene with formaldehyde or CH2(NMe2)2 and anilines has been accomplished. Preliminary screening of thus obtained perhydro hexaazadibenzotetracenes for cytotoxic activity has been performed.
引用
收藏
页码：112 / 114
页数：3
相关论文
共 50 条
  • [1] New bis-oxalamides from trans-1,2-diaminocyclohexane
    Francisco Montero-Vazquez, Erick
    Martinez-Martinez, Francisco J.
    Padilla-Martinez, Itzia I.
    Antonia Carvajal-Garcia, M.
    Hernandez-Diaz, Julio
    ARKIVOC, 2008, : 276 - 282
  • [2] Chiral macrocyclic aliphatic oligoimines derived from trans-1,2-diaminocyclohexane
    Kwit, Marcin
    Plutecka, Agnieszka
    Rychlewska, Urszula
    Gawronski, Jacek
    Khlebnikov, Alexander F.
    Kozhushkov, Sergei I.
    Rauch, Karsten
    de Meijere, Armin
    CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (31) : 8688 - 8695
  • [3] (±)-trans-1,2-Diaminocyclohexane crystallises as a conglomerate
    Kostyanovsky, RG
    Lakhvich, FA
    Philipchenko, PM
    Lenev, DA
    Torbeev, VY
    Lyssenko, KA
    MENDELEEV COMMUNICATIONS, 2002, (04) : 147 - 149
  • [4] Facile monoprotection of trans-1,2-diaminocyclohexane
    Kaik, M
    Gawronski, J
    TETRAHEDRON-ASYMMETRY, 2003, 14 (11) : 1559 - 1563
  • [5] A new approach to enantiomerically pure bis-imidazoles derived from trans-1,2-diaminocyclohexane
    Mucha, Paulina
    Mloston, Grzegorz
    Jasinski, Marcin
    Linden, Anthony
    Heimgartner, Heinz
    TETRAHEDRON-ASYMMETRY, 2008, 19 (13) : 1600 - 1607
  • [6] Optically active imidazoles derived from enantiomerically pure trans-1,2-diaminocyclohexane
    Mloston, Grzegorz
    Rygielska, Dorota
    Jasinski, Marcin
    Heimgartner, Heinz
    TETRAHEDRON-ASYMMETRY, 2011, 22 (06) : 669 - 674
  • [7] Prominent gelation and chiral aggregation of alkylamides derived from trans-1,2-diaminocyclohexane
    Hanabusa, K
    Yamada, M
    Kimura, M
    Shirai, H
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (17): : 1949 - 1951
  • [8] Folding of aromatic oligoimides of trans-1,2-diaminocyclohexane
    Gawronski, J
    Gawronska, K
    Grajewski, J
    Kacprzak, K
    Rychlewska, U
    CHEMICAL COMMUNICATIONS, 2002, (06) : 582 - 583
  • [9] New Class of Chiral, Inclusion Forming Crystals with Host Molecules Derived from trans-1,2-Diaminocyclohexane
    Rychlewska, Urszula
    Plutecka, Agnieszka
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2006, 62 : S222 - S222
  • [10] Synthesis and structure of N,N'-diaryl derivatives of trans-1,2-diaminocyclohexane
    Kwit, M
    Kubicki, M
    Borowiak, T
    Gawronski, J
    POLISH JOURNAL OF CHEMISTRY, 2003, 77 (11) : 1669 - 1682
12345